Possible association between stem-like hallmark and radioresistance
in human cervical carcinoma cells.
AMPK-independent autophagy promotes radioresistance
of human tumor cells under clinical relevant hypoxia in vitro.
It was anticipated that acute effects would be at an acceptable level, given the documented, relative radioresistance
of birds compared with other veterinary patients.
A similar phenomenon called hormesis is frequently found in the radiosensitivity or radioresistance
assays where low doses of ionizing radiation are more toxic than higher ones, because of cancer cells adaptation to the toxic conditions at higher doses of IR .
In fact, it has been shown that tumor hypoxia induces both radioresistance
and chemoresistance in glioblastoma preclinical in vitro and in vivo models [37, 38].
Vaughan, "The increase in radioresistance
of Chinese hamster cells cultured as spheroids is correlated to changes in nuclear morphology," Radiation Research, vol.
Brunauer et al., "Mesenchymal stem cells show radioresistance
in vivo," Journal of Cellular and Molecular Medicine, vol.
Zhang et al., "MicroRNA 23b regulates autophagy associated with radioresistance
of pancreatic cancer cells," Gastroenterology, vol.
The maintenance of intact HIPK2 function is important in anticancer therapy, and its functional inhibition appears to be associated with chemoresistance and radioresistance
[17, 18, 32].
Approximately 80% of HNSCC also exhibit up-regulation of persistent STAT3 expression, which can mediate radioresistance
Genotoxic effects, its modulation by polyvitamin treatment and evaluation of the induced radioresistance
. Mutat Res.
(91) Not all studies have consistently demonstrated the association between EGFR expression and radioresistance
. For example, 25 patients with laryngeal SCC who received postoperative radiation therapy showed no association between EGFR expression and risk of recurrence.