radiolabelling


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Related to radiolabelling: autoradiography

radiolabelling

A method of tagging and following the movement of a molecule by incorporating into it a radioactive atom. In genetics, radiolabelling is commonly used for the purposes of HYBRIDIZATION PROBING.
References in periodicals archive ?
In contrast, DOTA-conjugates have to be heated for efficient radiolabelling with gallium-68 and in case of oxidation sensitivity of the targeting probe additives (e.g., ascorbic acid) are needed to improve radiochemical purity.
However, the radiolabelling of the carbonyl group of carbonates from [[sup.11]C]C[O.sub.2] has not yet been established.
Breeman, "Scaled-up radiolabelling of DOTATATE with[sup.68]Ga eluted from a SnO2-based[sup.68]Ge/[sup.68]Ga generator," Applied Radiation and Isotopes, vol.
Since the longer half-life of Zirconium-89 ([sup.89]Zr) and Iodine-124 ([sup.124]I) matches the circulation half-lives of monoclonal antibodies (mAbs), theses isotopes have been used in the radiolabelling and evaluation of mAbs (Immuno-PET).
Therefore, new methodologies were developed to replace [sup.111]In with [sup.99m]Tc for ex vivo cell labelling, and in 1986,[sup.99m]Tc-HMPAO entered in clinical practice for WBC radiolabelling and imaging of occult sites of infection [7].
These include cGMP API and intermediate manufacture, process research and development, analytical method development and validation, and radiolabelling.
Almac has extended its radiolabelling services to include drug product--moving the company into the forefront of GMP radiolabelling.
Andersson, "Methods for radiolabelling of monoclonal antibodies," Methods in Molecular Biology, vol.
Tenders invited for Trodat-1 (ligand for radiolabelling with 99mtc, 5x10 mg)
Kownacka et al., "Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions," Nanoscale, vol.
Althought the calixerene ligands proved ultimately to be unsuitable as radiolabelling molecules, follow up work including photophysics and molecular structure characterisation by DAlessio has shown ligands with two tetrazoles are much better for making large cluster compounds than ligands with four tetrazoles.
Thebifunctional chelator DFO-NCS (Macrocyclics, Dallas, TX) was conjugated to LEM2/15, and subsequent [sup.89]Zr radiolabelling was performed by adaptation of published protocols [20, 21].