radiolabelling


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Related to radiolabelling: autoradiography

radiolabelling

A method of tagging and following the movement of a molecule by incorporating into it a radioactive atom. In genetics, radiolabelling is commonly used for the purposes of HYBRIDIZATION PROBING.
References in periodicals archive ?
In contrast, DOTA-conjugates have to be heated for efficient radiolabelling with gallium-68 and in case of oxidation sensitivity of the targeting probe additives (e.g., ascorbic acid) are needed to improve radiochemical purity.
However, the radiolabelling of the carbonyl group of carbonates from [[sup.11]C]C[O.sub.2] has not yet been established.
Breeman, "Scaled-up radiolabelling of DOTATATE with[sup.68]Ga eluted from a SnO2-based[sup.68]Ge/[sup.68]Ga generator," Applied Radiation and Isotopes, vol.
Since the longer half-life of Zirconium-89 ([sup.89]Zr) and Iodine-124 ([sup.124]I) matches the circulation half-lives of monoclonal antibodies (mAbs), theses isotopes have been used in the radiolabelling and evaluation of mAbs (Immuno-PET).
Therefore, new methodologies were developed to replace [sup.111]In with [sup.99m]Tc for ex vivo cell labelling, and in 1986,[sup.99m]Tc-HMPAO entered in clinical practice for WBC radiolabelling and imaging of occult sites of infection [7].
These include cGMP API and intermediate manufacture, process research and development, analytical method development and validation, and radiolabelling.
Almac has extended its radiolabelling services to include drug product--moving the company into the forefront of GMP radiolabelling.
Andersson, "Methods for radiolabelling of monoclonal antibodies," Methods in Molecular Biology, vol.
Kownacka et al., "Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions," Nanoscale, vol.
Thebifunctional chelator DFO-NCS (Macrocyclics, Dallas, TX) was conjugated to LEM2/15, and subsequent [sup.89]Zr radiolabelling was performed by adaptation of published protocols [20, 21].