radioimmunotherapy


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radioimmunotherapy

 [ra″de-o-im-mu″no-ther´ah-pe]
use of radionuclides to deliver monoclonal antibodies to targeted cancer cells.

radioimmunotherapy

Immunology The use of radio-labeled–monoclonal antibodies that recognize specific antigens, and therefore concentrate in a particular tissue to treat disease Toxicity Myelosuppression, nausea, infections, cardiopulmonary toxicity

radioimmunotherapy

(rā′dē-ō-ĭm″ū-nō-thĕr′ă-pē)
The use of radioactively labeled monoclonal antibodies to treat malignancies, e.g., breast cancers, non-Hodgkin's lymphoma, and prostate cancer. The monoclonal antibodies selectively bind with antigens on the tumor cells and deliver a dose of cell-killing radiation directly to those cells.
References in periodicals archive ?
Since joining IDEC in 1992, Matsui was employed as senior vice president of its investor relations, corporate communications, human resources, project management and strategic planning; collaboration chair for the late stage development and commercialization of rituximab as well as project leader for the radioimmunotherapy Zevalin.
Verastem announced that the results of the Phase 2 DYNAMO study, which evaluated COPIKTRA capsules in patients with indolent non-Hodgkin lymphoma who were refractory to both rituximab and chemotherapy or radioimmunotherapy, was published online in the Journal of Clinical Oncology.
Targeting radioimmunotherapy of hepatocellular carcinoma with iodine (1311) metuximab injection: clinical phase I/II trials.
However, the science behind radioimmunotherapy is based primarily on data from animal models and has not been fully evaluated in patients.
Given the poor prognosis, there are several ongoing clinical trials investigating other agents, such as Irinotecan, Temozolomide and Bevacizumab in Combination with Existing High Dose Alkylator Based Chemotherapy and Phase I Trial of Intraperitoneal Radioimmunotherapy with [sup.131]I-8H9 [25, 26].
Batra, "Optimization of radioimmunotherapy of solid tumors: biological impediments and their modulation," Clinical Cancer Research, vol.
Niessner et al., "Repeated adjuvant anti-CEA radioimmunotherapy after resection of colorectal liver metastases: safety, feasibility, and long-term efficacy results of a prospective phase 2 study," Cancer, vol.
Surgery, chemotherapy, radiotherapy, and radioimmunotherapy are different weapons to fight with GI lymphoma [22].
In the case of radioimmunoconjugates, a multistep pretargeted radioimmunotherapy approach that employs GD2-specific antibody-streptavidin constructs is justified.
(8) When used in radioimmunotherapy applications, a radioactive dose of mAb can be used to deliver a lethal chemical dose to specific target cells with minimal damage to surrounding tissues.
Visit Monoclonal Antibody Therapeutics Market by Source Type (Chimeric and Humanized, Human, Murine, Others), Therapy Type (Antibody-Directed Enzyme Prodrug Therapy, Antibody-Drug Conjugates, Radioimmunotherapy), Application (Autoimmune Diseases, Cancer, Hematological Diseases, Infection, Ophthalmological Diseases, Others), and End User (Hospitals, Private Clinics, Research Institutes) and Forecast 2017-2021 at https://www.ihealthcareanalyst.com/report/monoclonal-antibody-therapeutics-market/
PET scanning of iodine-124-3F9 as an approach to tumor dosimetry during treatment planning for radioimmunotherapy in a child with neuroblastoma.