radioallergosorbent test


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Related to radioallergosorbent test: immunoglobulin E

radioallergosorbent test

 (RAST) [ra″de-o-al″er-go-sor´bent]
a radioimmunoassay for the measurement of extremely small amounts of specific IgE antibody to a variety of allergens in the serum of a patient, using an allergen complex fixed in a solid-phase matrix, passing the serum over the matrix so the allergen can catch and bind specific IgE antibodies, and detecting the antibody using radiolabeled anti–human IgE antibody. Uptake of the labeled antibody is proportional to the level of specific serum IgE antibodies to the allergen. RAST is used as an alternative to skin tests to determine sensitivity to suspected allergens.

ra·di·o·al·ler·go·sor·bent test (RAST),

a radioimmunoassay test to detect specific IgE antibodies responsible for hypersensitivity: the allergen is bound to insoluble material and the patient's serum is reacted with this conjugate; if the serum contains antibody to the allergen, it will be complexed to the allergen. Radiolabeled anti-human IgE antibody is added where it reacts with the bound IgE. The amount of radioactivity is proportional to the serum IgE.

radioallergosorbent test (RAST)

[rā′dē·ō′alur′gōsôr′bənt]
Etymology: L, radius + Gk, allos, other, ergein, to work; L, absorbere, to swallow
a test in which a technique of radioimmunoassay is used to identify and quantify IgE in serum that has been mixed with any of 45 known allergens. If an atopic allergy to a substance exists, an antigen-antibody reaction occurs with characteristic conjugation and clumping. The test is an in vitro method of demonstrating allergic reactions. Compare patch test, Prausnitz-Küstner test.

radioallergosorbent test

An allergy test on peripheral blood that assesses allergic sensitivity to specific substances. See RAST.

ra·di·o·al·ler·go·sor·bent test

(RAST) (rā'dē-ō-al'ĕr-gō-sōr'bĕnt test)
A radioimmunoassay-based procedure to detect IgE-bound allergens responsible for tissue hypersensitivity: the allergen is bound to insoluble material and the patient's serum is reacted with this conjugate; if the serum contains antibody to the allergen, it will be complexed to the allergen.

ra·di·o·al·ler·go·sor·bent test

(RAST) (rā'dē-ō-al'ĕr-gō-sōr'bĕnt test)
A radioimmunoassay-based procedure to detect IgE-bound allergens responsible for tissue hypersensitivity.

radioallergosorbent test (RAST) (rā´dēōəler´gōsor´bənt),

n a test to determine whether an atopic allergy to a substance exists. A radioimmunoassay is used to identify and quantify IgE in serum that has been mixed with any of 45 known allergens. This is an in vitro method of demonstrating allergic reactions, as opposed to the patch test, which is the common in vivo method of determining allergens.
References in periodicals archive ?
Atopy patch testing had a higher degree of specificity but less sensitivity than skin prick testing and radioallergosorbent test in detection of allergens triggering atopic dermatitis.
Some physicians prefer to use a blood test called the radioallergosorbent test, or RAST, to diagnose food allergies.
Male sex, a positive skin-prick or radioallergosorbent test (RAST), and the presence of other atopic diseases are correlated with eosinophilic esophagitis.