radioallergosorbent test


Also found in: Dictionary, Thesaurus, Legal, Financial, Acronyms, Encyclopedia, Wikipedia.
Related to radioallergosorbent test: immunoglobulin E

radioallergosorbent test

 (RAST) [ra″de-o-al″er-go-sor´bent]
a radioimmunoassay for the measurement of extremely small amounts of specific IgE antibody to a variety of allergens in the serum of a patient, using an allergen complex fixed in a solid-phase matrix, passing the serum over the matrix so the allergen can catch and bind specific IgE antibodies, and detecting the antibody using radiolabeled anti–human IgE antibody. Uptake of the labeled antibody is proportional to the level of specific serum IgE antibodies to the allergen. RAST is used as an alternative to skin tests to determine sensitivity to suspected allergens.

ra·di·o·al·ler·go·sor·bent test (RAST),

a radioimmunoassay test to detect specific IgE antibodies responsible for hypersensitivity: the allergen is bound to insoluble material and the patient's serum is reacted with this conjugate; if the serum contains antibody to the allergen, it will be complexed to the allergen. Radiolabeled anti-human IgE antibody is added where it reacts with the bound IgE. The amount of radioactivity is proportional to the serum IgE.

radioallergosorbent test

An allergy test on peripheral blood that assesses allergic sensitivity to specific substances. See RAST.

ra·di·o·al·ler·go·sor·bent test

(RAST) (rā'dē-ō-al'ĕr-gō-sōr'bĕnt test)
A radioimmunoassay-based procedure to detect IgE-bound allergens responsible for tissue hypersensitivity: the allergen is bound to insoluble material and the patient's serum is reacted with this conjugate; if the serum contains antibody to the allergen, it will be complexed to the allergen.

ra·di·o·al·ler·go·sor·bent test

(RAST) (rā'dē-ō-al'ĕr-gō-sōr'bĕnt test)
A radioimmunoassay-based procedure to detect IgE-bound allergens responsible for tissue hypersensitivity.
References in periodicals archive ?
(1) Nonstandard abbreviations: TSH, thyrotropin; [T.sub.3], triiodothyronine; [fT.sub.3], free [T.sub.3]; and RAST, radioallergosorbent test. Table 1.
The laboratories used 5 different assays: 2 used ImmunoCAP (cellulose sponge), 1 used AlaSTAT (liquid-phase carrier), and 3 used modified radioallergosorbent tests (RAST; paper disks).
One of the earliest was the radioallergosorbent test (RAST), which involved the placement of a radioactive label on an anti-IgE antibody.
Direct enzyme-linked immunosorbent assay (ELISA), ELISA inhibition, direct radioallergosorbent test (RAST), RAST inhibition, Western blot or Western inhibition, or similar assay can be used to measure antigen-specific serum IgE.
The allergy assays included a prick test (level I), a radioallergosorbent test (level II), and a specific nasal provocation test (level III).
Urticaria is one of the most common reactions to penicillin, and 24% of a Scandinavian group of patients suffering from chronic idiopathic urticaria were found to have penicillin allergies.[6] In addition, penicillin has been shown to exacerbate chronic urticaria.[19] Ormerod et al noted that the radioallergosorbent test (RAST) has been used for the diagnosis of penicillin allergy, and correlates relatively well with prick-testing.[14] However, although it is more specific than intradermal testing, it is generally less sensitive and may miss some cases of penicillin allergy.
Only 17% of responding dermatologists indicated that they would evaluate such a patient for latex allergy, most commonly by radioallergosorbent test (RAST).