radiation sensitizer

radiation sensitizer

Oncology Any agent which ↑ cell susceptibility to ionizing radiation Explanation Most CA cells are hypoxic and thus more resistant to radiation; a hypoxic-cell RS–eg, etanidazole, misonidazole, nimorazole would, theoretically, improve radiation killing of CA cells–results have been disappointing. See Radiation therapy.
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The company said doranidazole is a hypoxic cell radiation sensitizer in clinical development for treating cancers in combination with stereotactic body radiation therapy.
Resveratrol, a potential radiation sensitizer for glioma stem cells both in vitro and in vivo.
Aim: To determine the efficacy of whole brain radiotherapy (WBRT) with carboplatin as radiation sensitizer in metastatic brain disease in our adult population.
Because the majority of nanosilica particles in CS/3-2/2R are confined in the EVA phase, consequently more crosslinking occurs in the EVA domains (nanosilica particles act as radiation sensitizer (28)).
Zelefsky said the research team conducted the retrospective study because published studies had suggested statins also may have an apoptotic effect, may act as a radiation sensitizer, and may reduce cancer risk.
Zelefsky said the team conducted the retrospective study because published studies had suggested statins also may have an apoptotic effect, may act as a radiation sensitizer, and may reduce cancer risk.
Allos has two product candidates in late-stage clinical development: EFAPROXYN (efaproxiral), a radiation sensitizer currently under evaluation in a pivotal Phase 3 trial in women with brain metastases originating from breast cancer, and PDX (pralatrexate), a novel, next-generation antifolate currently under evaluation in a pivotal Phase 2 trial in patients with relapsed or refractory peripheral T-cell lymphoma.
Allos Therapeutics expects to use the proceeds from the financing for the development of the company's lead investigational radiation sensitizer, RSR13 (efaproxiral), and for general working capital.
The researchers reported that a significant number of randomized studies have demonstrated that the addition of hyperthermia to radiation can improve response rate, local control and overall survival without a significant increase in toxicity, which makes hyperthermia a very attractive radiation sensitizer for radiation oncologists.
What some of the other trials underestimated is the capability of gemcitabine to serve as a radiation sensitizer, Dr.
In this trial, patients with advanced pancreatic cancer with no prior chemotherapy except as a radiation sensitizer received escalating doses of nab-paclitaxel (ABRAXANE([R])) from 100 mg/m2 to 150 mg/m2 combined with 1000 mg/m2 of gemcitabine.
The study is the first to demonstrate the utility of GRN163L as a radiation sensitizer in cancer therapy.

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