radiation sensitizer

radiation sensitizer

Oncology Any agent which ↑ cell susceptibility to ionizing radiation Explanation Most CA cells are hypoxic and thus more resistant to radiation; a hypoxic-cell RS–eg, etanidazole, misonidazole, nimorazole would, theoretically, improve radiation killing of CA cells–results have been disappointing. See Radiation therapy.
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Resveratrol, a potential radiation sensitizer for glioma stem cells both in vitro and in vivo.
Roman et al., "Carboplatin as a radiation sensitizer in locally advanced cervical cancer: a pilot study," Gynecologic Oncology, vol.
Aim: To determine the efficacy of whole brain radiotherapy (WBRT) with carboplatin as radiation sensitizer in metastatic brain disease in our adult population.
Conclusion: WBRT with carboplatin as radiation sensitizer is effective in palliation of patients with metastatic brain disease.
Because the majority of nanosilica particles in CS/3-2/2R are confined in the EVA phase, consequently more crosslinking occurs in the EVA domains (nanosilica particles act as radiation sensitizer (28)).
Zelefsky said the research team conducted the retrospective study because published studies had suggested statins also may have an apoptotic effect, may act as a radiation sensitizer, and may reduce cancer risk.
Zelefsky said the team conducted the retrospective study because published studies had suggested statins also may have an apoptotic effect, may act as a radiation sensitizer, and may reduce cancer risk.
Allos has two product candidates in late-stage clinical development: EFAPROXYN (efaproxiral), a radiation sensitizer currently under evaluation in a pivotal Phase 3 trial in women with brain metastases originating from breast cancer, and PDX (pralatrexate), a novel, next-generation antifolate currently under evaluation in a pivotal Phase 2 trial in patients with relapsed or refractory peripheral T-cell lymphoma.
Allos Therapeutics expects to use the proceeds from the financing for the development of the company's lead investigational radiation sensitizer, RSR13 (efaproxiral), and for general working capital.
What some of the other trials underestimated is the capability of gemcitabine to serve as a radiation sensitizer, Dr.
Current radiation dose limitations, due to sensitive normal tissues that may surround a tumor, support a role for radiation sensitizers to enhance the effectiveness of radiation.
"The NCI [National Cancer Institute] is interested in exploring the radiosurgery platform as a way of testing novel therapeutics as radiation sensitizers, but because the radiation therapy is so exquisitely tuned to the actual cancer target, there is an opportunity to study whether or not there are systemic effects of the novel drugs as well.

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