radiation pneumonitis


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pneumonitis

 [noo″mo-ni´tis]
inflammation of the lung; see also pneumonia.
hypersensitivity pneumonitis a respiratory hypersensitivity reaction to repeated inhalation of organic particles, usually in an occupational setting, with onset a few hours after exposure to the allergen. Many different substances are potential causes of the condition; see bagassosis, farmer's lung, and pigeon breeder's lung. Characteristics include fever, fatigue, chills, unproductive cough, tachycardia, and tachypnea; in the chronic form there is interstitial fibrosis with collagenous thickening of the alveolar septa. Called also extrinsic allergic alveolitis.
radiation pneumonitis lung inflammation resulting from radiation exposure, usually radiation therapy, with coughing, dyspnea, and alveolar infiltration of secretions, leading to mild to severe or even fatal fibrosis 6 to 9 months after the exposure.

ra·di·a·tion pneu·mo·ni·tis

the interstitial pneumonia and fibrosis that follow pulmonary irradiation at radiotherapeutic doses.

radiation pneumonitis

Irradiation pneumonitis Pulmonology A condition caused by exposure of lung tissue to radiation, a common complication of RT to mediastinal and thoracic tumors–eg, NHLs, Hodgkin's disease, breast and esophageal CAs; frequency of RP reflects dose and amount of tissue exposed to radiation Incidence RP occurs in 65% of irradiated lung fields; clinical pneumonitis occurs in 6%, 2% die from RP. See Radiation fibrosis.
References in periodicals archive ?
Symptomatic Radiation Pneumonitis in Elderly Patients Receiving Thoracic Irradiation.
Clinical relevance of radiation pneumonitis in breast cancers.
The studies described toxicities, such as radiation pneumonitis, chronic myositis and radiation-induced dermatitis occurring post-SABR [36-39].
Radiation pneumonitis of grade 2 or higher was experienced by 7% of patients [37,38].
Suh, "Factors predicting radiation pneumonitis in locally advanced non-small cell lung cancer," Radiation Oncology Journal, vol.
Radiation pneumonitis and fibrosis: Mechanisms underlying its pathogenesis and implications for future research.
Animal studies showed that short-term steroid administration delays radiation pneumonitis in rats [12] and reduces radiation-related inflammation in a mouse model of RILI [13].
Martel, "Lung size and the risk of radiation pneumonitis," International Journal of Radiation Oncology Biology Physics, vol.
[18] reported that an MLD-based model is better than other models for radiation pneumonitis. In our study, significant differences were not observed in the lung V5 and V20 among the IMRT groups.
[sup][2],[3],[4] EBRT cannot avoid adjacent normal tissues and may cause radiation pneumonitis, esophagitis, and medullitis.
Photomicrograph of the lung showing radiation pneumonitis, section, H & E stain, mag.
Mice on flaxseed displayed improved survival rates and mitigation of radiation pneumonitis, with increased blood oxygenation levels, higher body weight, lower pro-inflammatory cytokine levels, and greatly reduced pulmonary inflammation and fibrosis.

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