(46) Chris Holman argues that "there is no general expectation that separating a racemate
into its constituent enantiomers will provide any benefit." Christopher M.
De Almeida, "Anticonvulsant activity of the linalool enantiomers and racemate
: investigation of chiral influence," Natural Product Communications, vol.
In studying the crystals of the two molecules under the microscope, Pasteur made a remarkable discovery--although ammonium sodium tartrate (a salt of tartaric acid) was composed of only one type of crystal, ammonium sodium racemate
was composed of an equal mixture of two very slightly different crystals.
The 6,7-dimethyl derivative of AC7954 showed the most potency among the series ([pEC.sub.50] = 6.87 [+ or -] 0.03) and once its racemate
has been resolved into the pure enantiomers, it was indicated the (+)-enantiomer, subsequently named FL-68 (Figure 3), as the own potential active stereoisomer ([pEC.sub.50] = 7.30).Fromthe series of compounds synthesized in this study, FL-68 was found the most interesting since it was very active versus UT receptor and not showing at the same time any activity versus the closely related somatostatin receptors.
Chemically, LCT is the active L-enantiomer of cetirizine racemate
. It works by blocking [H.sub.1] histamine receptors.
The dry membrane specimens were immersed in aqueous Trp racemate
solutions with a concentration of 1 mg/mL at 25[degrees]C for 48 h to reach sorption equilibrium.
The components observed are: a) tricyclene, (b) (-) -[alpha]-pinene, (+)-[alpha]-pinene racemate
, (c) camphene, (d) 1,4-cineole (e), limonene, (f) terpinolene, and (g) turpineol.
Pharmacokinetics of the R- and S-enantiomers of oxybutynin and N-desethyloxybutynin following oral and transdermal administration of the racemate
in healthy volunteers.
The new portfolio of ready-to-use kits reduces development time to just one day, with as little as 0.4mmol of racemate
Mice also received warfarin (racemate
, (S)- or (R)-enantiomer) for the last 3 days of the 5-day regimen to examine GBE-warfarin interactions.
The reason that the CHMP determined that eszoplicone should not be granted new active substance status was because Sepracor failed to prove relevant and clinically meaningful differences between eszopiclone and the racemate
of which it was the active enantiomer, zopiclone in an adequate planned clinical trial with direct head to head comparison.
Five of Hurricane Run's black-type winners broke through at stakes level from September onwards, namely Mohedian Lady (who set a course record when running away with the Princess Royal Stakes at Newmarket), Freedom, Charleston Lady, Barbican and Racemate
. The last two were successful in Listed races over 1m4f and 1m5f last week and appeal as types to improve significantly next year.