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rabeprazole/ra·bep·ra·zole/ (rah-bep´rah-zōl) a proton pump inhibitor used as the sodium salt to inhibit gastric acid secretion in the treatment of gastroesophageal reflux disease and conditions marked by excessive secretion of gastric acid.
a proton pump inhibitor.
indications Rabeprazole is used to treat gastroesophageal reflux disease (GERD), severe erosive esophagitis, poorly responsive systemic GERD, pathological hypersecretory conditions such as Zollinger-Ellison syndrome, systemic mastocytosis, multiple endocrine adenomas, and active duodenal ulcers.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Life-threatening effects are proteinuria, hematuria, pancytopenia, thrombocytopenia, neutropenia, and leukocytosis. Other adverse effects include abdominal swelling, anorexia, irritable colon, esophageal candidiasis, epistaxis, urticaria, alopecia, hypoglycemia, increased hepatic enzymes, weight gain, tinnitus, angina, tachycardia, bradycardia, palpitations, peripheral edema, urinary tract infection, increased creatinine, testicular pain, glycosuria, and fever. Common side effects include headache, dizziness, asthenia, diarrhea, abdominal pain, vomiting, nausea, constipation, flatulence, acid regurgitation, upper respiratory infections, cough, rash, and back pain.