rabeprazole


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Related to rabeprazole: Pantoprazole, rabeprazole sodium, Domperidone

rabeprazole

 [rah-bep´rah-zōl]
an inhibitor of stomach hydrochloric acid secretion administered orally as the sodium salt in treatment of gastroesophageal reflux disease and similar conditions marked by excessive acid.

rabeprazole

/ra·bep·ra·zole/ (rah-bep´rah-zōl) a proton pump inhibitor used as the sodium salt to inhibit gastric acid secretion in the treatment of gastroesophageal reflux disease and conditions marked by excessive secretion of gastric acid.

rabeprazole

a proton pump inhibitor.
indications Rabeprazole is used to treat gastroesophageal reflux disease (GERD), severe erosive esophagitis, poorly responsive systemic GERD, pathological hypersecretory conditions such as Zollinger-Ellison syndrome, systemic mastocytosis, multiple endocrine adenomas, and active duodenal ulcers.
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Life-threatening effects are proteinuria, hematuria, pancytopenia, thrombocytopenia, neutropenia, and leukocytosis. Other adverse effects include abdominal swelling, anorexia, irritable colon, esophageal candidiasis, epistaxis, urticaria, alopecia, hypoglycemia, increased hepatic enzymes, weight gain, tinnitus, angina, tachycardia, bradycardia, palpitations, peripheral edema, urinary tract infection, increased creatinine, testicular pain, glycosuria, and fever. Common side effects include headache, dizziness, asthenia, diarrhea, abdominal pain, vomiting, nausea, constipation, flatulence, acid regurgitation, upper respiratory infections, cough, rash, and back pain.

rabeprazole

Aciphex® GI disease A proton pump inhibitor used to manage for heartburn, duodenal ulcers, gastric ulcers, GERD, hypersecretory conditions–eg, Zollinger-Ellison syndrome. See GERD.
References in periodicals archive ?
Ltd (TYO: 4523) to market the Japanese drug firm's anti-ulcer drug, rabeprazole, in India, Money Control reported on Wednesday.
5 Different drugs like rabeprazole esomeprazole lansoprazole pantoprazole and ome- prazole are used to decrease the gastric acid secretion and increase pH of gastric juice thus reducing the risk of aspiration.
The aim of this study was to investigate and compare the eradication rate of third-line triple therapy with rabeprazole (RPZ) + AMPC + LVFX to high-dose RPZ + AMPC which were suggested in the guidelines of the Japanese Society of Helicobacter Research in 2009.
The authors found no significant difference between neoplastic progression and the various PPIs assessed in this study (including esomeprazole and pantoprazole as well as omeprazole, rabeprazole, and lansoprazole).
Her medications included metformin, levothyroxine, sertraline, rosuvastatin, and rabeprazole.
Information was also collected on the specific PPI drugs used along with their respective doses; these drugs were esomeprazole, lansoprazole, omeprazole, pantoprazole and rabeprazole.
Her medications included amlodipine, lisinopril, venlafaxine, bromazepam, carbidopa, levodopa and rabeprazole.
All PPIs except rabeprazole are metabolized by the P450 system enzyme CYP 2C19.
PPIs also have antibacterial activity against Helicobacter pylori and rabeprazole is the most effective amongst different PPIs.
However, the researchers concede that further studies are required to determine whether newer, less widely used PPIs-such as rabeprazole (Aciphex) and dexlansoprazole (Kapidex)-are also associated with increased cardiovascular risk in patients taking clopidogrel.