The effect of single oral dose of sodium rabeprazole
20 mg, administered at 21:00 h, was examined on intragastric pH and volume in 120 adult consecutive inpatients of American Society of Anesthesiologists (ASA) physical status I (a normal healthy patient) and class-II (a patient with mild systemic disease and no functional limitations)4 to be intubated with cuffed endotracheal tube in the Operating Rooms of King Khalid University Hospital, Al-Riyadh, Saudi Arabia, from August 2006 to November 2006.
TABLE Potential proton pump inhibitor safety concerns Safety concern PPI studied Gastric carcinoids Omeprazole, lansoprazole, pantoprazole, rabeprazole
Gastric metaplasia/ Omeprazole adenocarcinoma Enteric infections Omeprazole Mineral malabsorption Omeprazole B12 malabsorption Omeprazole Safety concern Duration of studies Gastric carcinoids 1-8 years Gastric metaplasia/ 1-5 years adenocarcinoma Enteric infections 1 year Mineral malabsorption 6 months-2 years B12 malabsorption 10 years Safety concern Evidence Gastric carcinoids No increased risk (1-5) Gastric metaplasia/ No increased risk (1-3,5) adenocarcinoma Enteric infections No increased risk (6) Mineral malabsorption No increased risk (1,3) B12 malabsorption Decreased B12 levels with high-dose therapy (1,2) REFERENCES
The results of the study showed a statistically significant reduction in the cumulative incidence of recurrent gastric or duodenal ulcer among the patient groups administered 5 mg and 10 mg of rabeprazole
, respectively, when compared to a comparator, thereby demonstrating the superiority of rabeprazole
in preventing ulcer recurrence.
Effects of Rabeprazole
Dose and Treatment Course on Coincident Rate of the Rabeprazole
There is some evidence that rabeprazole
(10 mg) may provide better symptom control than esomeprazole (40 mg) at 4 weeks, and that pantoprazole (40 mg) may improve symptoms better than esomeprazole (40 mg) at 24 weeks.
Overall, 42 patients took rabeprazole
20 mg twice daily for 12 weeks, 30 minutes prior to lunch and dinner (mean age, 46 years; 15 males), while the remaining 40 subjects were given placebo (mean age, 47 years; 8 males).
Particularly enlightening was the rationale for specific agents: aluminum phosphate has efficacy as an antacid; ranitidine is the only studied [H.sub.2]-blocker; and there are 3 FDA category B proton pump inhibitors (pantoprazole, lansoprazole, and rabeprazole
Pharmaceutical company Mylan Inc (NasdaqGS:MYL) said on Monday that its US subsidiary Mylan Pharmaceuticals Inc has launched Rabeprazole
Sodium Delayed-release Tablets, 20 mg.
(Headquarters: Tokyo, President & CEO: Haruo Naito, "Eisai") announced today that it has received marketing authorization from Japan's Ministry of Health, Labour and Welfare for two types of triple formulation packs (combination packs) that contain its proton pump inhibitor Pariet (rabeprazole
sodium) for Helicobacter pylori eradication.
The proton pump inhibitor rabeprazole
had a small, but significant effect in reducing laryngopharyngeal reflux symptoms after 12 weeks of treatment, Dr.
PPIs--which include prescription esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix) and rabeprazole
(Aciphex), as well as over-the-counter Prilosec OTC--may inhibit an enzyme that converts clopidogrel into its active form, reducing the drug's effectiveness, the FDA noted.
These agents, used for heartburn and GERD, include the histamine [H.sub.2] antagonists cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac) and the proton pump inhibitors esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole