Keywords: Rabdosia japanica Diterpenes Melanin production inhibitor
The genus of Rabdosia (formerly known as Isodon) belonging to Labiatae (Nara 1972, 1985) is a rich source of diterpenoids, especially highly oxygenated ent-kaurenoids (Fujita and Node 1984; Takeda and Otsuka 1995).
alpha], [beta]-Unsaturated ketone group in the D-ring is a characteristic structural feature among many Rabdosia diterpenoids characterized (Fujita and Node 1984; Takeda and Otsuka 1995) and this moiety is responsible for eliciting the biological activities such as cytotoxicity and antimicrobial activity (Fujita et al.
According to the manufacturer, the formulation contained Chinese herbs (Isatis indigotica, Glycyrrhiza uralensis, Panax pseudo-ginseng, Ganoderma lucidium, Scutellaria baicalensis, Dendranthema morifolium, and Rabdosia
rubescens), as well as one domestic American herb (Serenoa repens).
Effects of phenolic compounds isolated from Rabdosia
japonica on B16-F10 melanoma cells.
The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia albescens, on tumor cells of different lineage.
Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.
Among them, oridonin, which is an active diterpenoid isolated from Rabdosia
Rubescens, has been traditionally and widely used for treatment of various human diseases due to its unique biological function (e.
The EtOAc extract of Rabdosia coetsa showed angiotensin-converting enzyme (ACE) inhibitory activity.
Keywords: Rabdosia coetsa; Rosmarinic acid; Angiotensin-converting enzyme inhibitor
Some plants of the genus Rabdosia (Labiatae) are used for gastrointestinal disorders in Japan, and used as antitumor and antiphlogistic agents in China (Fujita and Node, 1984).
2003) with potential use in primary healthcare, and that this genus is related to Salvia, Coleus and Rabdosia
genera (Alvarenga et al.