quorum sensing


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quorum sensing

a phenomenon in bacteria that limits certain behaviors to occurring only above a certain population density.

quorum sensing

n.
A phenomenon in which a population of bacteria produces and responds to intercellular chemical signals whose concentration indicates the density of the population. When the density reaches a certain level, genes are expressed that allow for coordinated group behavior, as in bioluminescence or the formation of biofilms.

quo·rum sens·ing

(kwōr'ŭm sens'ing)
A process whereby bacteria communicate by means of extracellular molecules called pheromones.

quorum sensing

a process in which unicellular organisms secrete signal molecules that influence the behaviour of a population of identical organisms, but only when the density (number of cells per unit volume) of that population is above a certain level. Cells sense the concentration of the secreted signal molecule, often a homoserine lactone, which tells them how many other cells are in their environment. When a threshold concentration of the signal molecule is reached, the population density has achieved a critical level or quorum, and quorum-dependent genes are expressed by auto induction. A given species can produce a range of autoinducer signal molecules, which regulate expression of genes governing characteristics that are only exhibited above this critical population density Thus specific characteristics may be displayed by cells present at high density, but not by the same cells when present at low density Examples of quorum sensing include, bioluminescence of Photobacterium fischeri when occurring as a SYMBIONT in high density populations, but not when free-living in low density populations; promotion of COMPETENCE for TRANSFORMATION in Bacillus subtilis, when present at high density; and production of VIRULENCE factors in Pseudomonas aeruginosa.
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Molecular docking of Morin with DNA binding domain of agrA revealed it as the potential agent for quorum sensing thereby enabling it to be used against all staphylococcus bacteria including MRSA and other pathogens.
Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: Effects on small RNA and biofilm architecture.
Results indicating the presence of the Al-2 quorum sensing signaling molecules by detecting the presence of the luxS gene were corroborated by confirmation of the capacity to induce the phenomenon of bioluminescence in V.
pylori taking into account the dual quorum sensing system, including AI-2 and DSF compounds, and their function in modulating the physiology of this pathogen.
Levine et al., "Bacterial communication ("quorum sensing") via ligands and receptors: a novel pharmacologic target for the design of antibiotic drugs," The Journal of Pharmacology and Experimental Therapeutics, vol.
It is unclear whether these concentrations inhibit the quorum sensing system of G.
Zularisam, Targeting N-acyl-Homoserine-Lactones to Mitigate Membrane Biofouling based on Quorum Sensing using a Biofouling Reducer, J.
"They found that the regulator's suppressing abilities were activated by quorum sensing, which had never before been seen.
When Burkholderia cenocepacia biofilms were treated with quorum sensing inhibitors (QSI) such as baicalin hydrate which is one of the ingredients of the root of Scutellaria baicalensis, B.
[34] reported that cinnamaldehyde would influence signaling pathways of quorum sensing by interfering with the binding of 3-hydroxy-C4, 3-oxo-C6-HSL, and AI-2 synthetic pathway and Brackman et al.