The authors' work supports the role of MTAN in quorum sensing
and demonstrates the potential to regulate virulence through MTAN inhibition.
Our study is part of a series of comprehensive investigations of natural compounds targeting bacterial quorum sensing
systems, and it further strengthens previous proof of concept research we conducted on the potential of compounds which block communication among pathogen cells in contrast to simply killing bacteria, as conventional antibiotics do," says Jakobsen.
En nuestros dias el termino de quorum sensing
se usa para describir el fenomeno en el cual la acumulacion de moleculas senales permite a una celula individual percibir el numero de bacterias (densidad celular) que tiene a su alrededor por la deteccion y reaccion con estos compuestos, esto es suficiente para que las bacterias inicien la expresion coordinada de genes especificos, lo que implica un cambio en su comportamiento hacia una fase multicelular.
Secretions from normal bacteria reduced the ability of skin cells to fill the gap (a key process in wound healing called migration) substantially more than secretions from the strain with disabled quorum sensing
The bacteria on the pellicle undergo cell to cell interaction via quorum sensing
Two different biosensors were used to evaluate the quorum sensing
inhibition properties of compounds and extracts.
Halting a quorum sensing
factor could one day translate to a treatment for bacterial infections.
The colonies are synchronized via the gas signal, but the cells are synchronized via quorum sensing
Henry Ji, chief scientific officer of Sorrento Therapeutics, said that this discovery programme represents a novel approach to fighting MRSA, and Sorento also sees interference with quorum sensing
as a more general approach to address the serious issue of antibiotic resistance beyond MRSA.
More important, quorum sensing
offers an open channel that scientists can tap to steer bacteria's small talk.
Spectrum expert commentary: an award-winning researcher explains how quorum sensing
may shine light on a new path to novel antibacterial drug development.
(QS) is a process of cell-cell communication mechanism occurs between the bacterial cells through the secretary signal molecules.