An agonist at glutamate receptors of the amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) type. The anion formed when quisqualic acid is dissolved in water. See: quisqualic acid.
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80, 81) At least three receptor types are generally accepted as being responsible for glutamate excitotoxicity--those selectively activated by NMDA, quisqualate, and kainate.
81) KYNA is a tryptophan metabolite that has selective activity against NMDA, quisqualate, and kainate receptors in the central nervous system.
Comparative actions of quisqualate and N-methyl-D-aspartate, excitatory amino acid agonists, on guinea-pig cochlear potentials.