quinupristin

quinupristin

 [kwin-u´pris-tin]
a semisynthetic antibacterial effective against a variety of gram-positive organisms. It is used in conjunction with dalfopristin in the treatment of serious bacteremia caused by vancomycin-resistant Enterococcus faecium and complicated skin and skin structure infections caused by Streptococcus pyogenes or methicillin-sensitive Staphylococcus aureus; administered intravenously.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

quinupristin

See Synercid®.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
For patients who have recently suffered from infection with vancomycin resistant Enterococcus (VRE) or MRSA, prophylaxis with linzolid, or quinupristin / dalfopristin can be considered.17 Common Pathogens likely to cause the post-operative infections at surgical site are almost the same as described by Chang and his collogues.18
(b) Dalfopristin is combined with quinupristin in the same product.
The agents we tested were penicillin (0.25-16 [micro]g/mL), erythromycin (0.25-8 [micro]g/mL), vancomycin (0.25-32 [micro]g/mL), daptomycin (0.25-16 [micro]g/ mL), chloramphenicol (2-32 [micro]g/mL), linezolid (0.5-8 [micro]g/ mL), tetracycline (1-32 [micro]g/mL), quinupristin (0.5-32 [micro]g/ mL), tigecycline (0.05-0,5 [micro]g/mL), streptomycin (512-2048 [micro]g/mL), kanamycin (128-1024 [micro]g/mL), lincomycin (1-8 [micro]g/mL), and gentamicin (128-1024 [micro]g/mL).
Treatment of methicillin - resistant Staphylococcus aureus infections with quinupristin - dalfopristin in patients intolerant of or failing prior therapy.
These drugs are streptogamins which contain two component types, A and B, which are represented by dalfoprisitin and quinupristin respectively.
Overall, 12 (50%) of 24 of the VRE samples had high levels of gentamicin resistance, 3 (12%) of 25 were resistant to quinupristin (Synercid), 13 (54%) of 24 were resistant to tetracycline, and 20 (83%) of 24 were resistant to penicillin.
aureus isolate by the disc diffusion method against cefoxitin, gentamicin, erythromycin, clindamycin, ciprofloxacin, cotrimoxazole, chloramphenicol, rifampin, doxycycline, quinupristin dalfopristin, linezolid and mupirocin.
aureus (n = 57) R (%) (n = 128) R (%) R (%) Tetracycline 36.8 28.2 32.0 Gentamicin 31.6 14.1 21.9 Penicillin 96.5 97.2 96.9 Oxacillin 100 0.0 44.5 Clindamycin 71.9 66.2 68.8 Erythromycin 71.9 67.6 69.5 Ciprofloxacin 36.8 15.5 25.0 Linezolid 0 0 0 Rifampicin 10.5 0 4.7 Trimethoprim/ 28.1 19.7 23.4 sulfamethoxazole Nitrofurantoin 0 0 0 Cefaclor 40.4 1.4 18.8 Chloroamphenicol 15.8 5.6 10.2 Imipenem 17.5 0 7.8 Mupirocin 1.8 0 0.8 Dalfopristin/ 0 0 0 quinupristin Vancomycin 0 0 0 Table 3--The frequencies of virulence genes among S.
It is a novel, injectable antibiotic made of two molecules: quinupristin and dalfopristin.
Synercid[R] is a medication composed of two components, quinupristin and dalfopristin, and is available as an injectable solution.
All of these linezolid-resistant isolates were still sensitive to the drug combination of quinupristin and dalfopristin (Synercid), but the relatively high prevalence of linezolid resistance is "a cause for concern," said Paul C.