, we can use smaller dosages of dextromethorphan" than might be required if the drug were used by itself and thereby avoid the lethargy that could occur in patients who might require larger dosages of dextromethorphan without quinidine
, he said in an interview.
After 10 weeks, the 93 patients on dextromethorphan plus quinidine
had their average neuropsychiatric inventory domain score for agitation and aggression cut roughly in half, compared with baseline, compared with about a 25% drop in average score among 66 control patients, a statistically significant difference for the study's primary endpoint, Dr.
Cellular mechanism underlying hypothermia-induced ventricular tachycardia/ventricular fibrillation in the setting of early repolarization and the protective effect of quinidine
, cilostazol, and milrinone.
The study compound's inhibition of CYP2D6 was negligible, ranging from -6.53% to 10.67%, compared with quinidine
's CYP2D6 linear dose-related increase from -7.07% at 2.06 nM to 84.05% at 500 nM.
Parenteral artesunate, an artemisinin that is a first-line treatment for severe malaria in many countries, is associated with increased survival and has a better safety profile than the parenteral alternatives, quinine and quinidine
. However, post-artemisinin delayed hemolysis (PADH) can occur 1-3 weeks after initiation of malaria treatment with drugs in the artemisinin class of antimalarials, resulting in anemia.
As noted earlier, cardiac toxicity has been a major concern with the use of IV quinine or quinidine
, with quinidine
considered to be more 4,6 toxic than quinine .
Dextromethorphan, dextrorphan, quinidine
, chlorpheniramine, [beta]-nicotinamide adenine dinucleotide phosphate (NADP), D-glucose 6-phosphate, glucose 6-phosphate dehydrogenase, heparin sodium, urethane, and phenacetin were from Sigma Chemical Co.
's half-life is approximately 6 h, but in 1 report recovery time was as long as 15-30 d following withdrawal of the drug.
According to press release issued here on Monday, the title of the poster was "Highly Selective Sulphur Ylide Mediated Asymmetric Epoxidations and Aziridinations Using an Inexpensive Chiral Sulfide; Applications to the Synthesis of Quinine and Quinidine
." Quinine is a well-known anti-malarial drug and its synthesis is considered a challenging task.
According to press release issued here on Monday, the title of the poster was Highly Selective Sulfur Ylide Mediated Asymmetric Epoxidations and Aziridinations Using an Inexpensive Chiral Sulfide; Applications to the Synthesis of Quinine and Quinidine
. Quinine is a well-known anti-malarial drug and its synthesis is considered a challenging task.
The company reformulated the drug with a lower dose of quinidine
and conducted new studies, she said.
Two reports noted that dextromethorphan plus quinidine
, previously shown to be helpful for pseudobulbar affect, was safe and tolerable.