The researchers implemented a model based on the table that predicts the expected frequencies of each quaternary structure topology, including those not yet observed.
"It also provides an overview of the evolutionary steps that are possible in the universe of protein complex topologies, allowing researchers to explore possible topologies in the context of determining quaternary structure assignments, and potentially also for bioengineering applications."
Gaining a protein quaternary structure dataset, we design our method Quad-PRE from primary sequence as below.
For confirming our generated new features (TOTAL) can improve the prediction of protein quaternary structure attributes, we compared the results from TOTAL features with those from each one of the six feature sets (ART_1, ART2, ART3, BLAST, GLAM2, and GIBBS), which are shown in Table 5.
To predict protein quaternary structure attribute is indeed a challenging problem.
Garian, "Prediction of quaternary structure from primary structure," Bioinformatics, vol.
Wang, "Classification of protein quaternary structure with support vector machine," Bioinformatics, vol.
Strategies need to be developed that allow RCF to be deconjugated while all Hb is in the T-state quaternary structure; this will usually, but not exclusively (34, 35), mean that all Hb will need to be in the deoxy-Hb state.
A search should be made for compounds that not only have a high binding affinity for Hb but can also cross-link the tetramer to permanently retain Hb in the T-state quaternary structure. In the interim, the usefulness of compounds that are already known to be synergistic with DPG (37, 38) should be examined.