, the sticky platelet syndrome is defined as a qualitative alteration of the platelet function and of autosomal dominant inheritance, characterized by platelet hyperaggregation in vitro with low concentrations of adenosine diphosphate (ADE) and/or epinephrine (EPI) but with normal aggregation in response to collagen, arachidonic acid, ristocetin, and thrombin .
The SPS was first described in the 80s as a thrombophilia in which qualitative alterations of the platelet function increase its aggregation capacity, favoring in this way thrombosis with described cases of cerebrovascular disease, acute myocardial infarction, and ischemic retinopathy .
Given the experienced difficulty in obtaining a plasma sample from a VWD patient, for whom a qualitative alteration of the subtype 2B has been undoubtedly confirmed, we have engineered a model protein as a manner to test the diagnostic usefulness of our produced antisera.
Such information is of relevance considering that high sensitivity for detecting qualitative alterations in the VWF in human plasma is obviously desirable.
Quantitative and/or qualitative alterations of gut microbiota, in other way defined as dysbiosis, are known to lead to disruption of this homeostasis and, consequently, development of pathology.
In addition, qualitative alterations of gut microbiota are able to interfere with the intestinal absorption of bile acid.
In addition, emphasis thus far has been on alterations in nutrition during development with virtually no focus on the role that exposures to environmental agents, such as air or water pollution, either alone or in combination with qualitative alterations
in macro- or micro-nutrition (i.e.
The findings suggest that subtle quantitative and qualitative alterations of acute-phase proteins may occur with normal physiological ageing in humans.
The results of this study provide support for the hypothesis that both quantitative and qualitative alterations of acute-phase protein production occur with physiological ageing in humans.
Emphasis thus far has been on alterations in nutrition during development with virtually no focus on the role that exposures to environmental agents--either alone or in combination with qualitative alterations
in macro- or micronutrition--might have on this phenomenon.