malate dehydrogenase(redirected from pyruvic-malic carboxylase)
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ma·late de·hy·dro·gen·ase (MD),
an enzyme that, using either NAD+ or NADP+, catalyzes the dehydrogenation of malate to oxaloacetate or its decarboxylation to pyruvate and CO2. At least six malate dehydrogenases are known, distinguished by their products, use of NAD+ or NADP+, and specificity of substrate (one acts on d-malate, the rest act on l-malate); one of these proteins is an enzyme in the tricarboxylic acid cycle.
Farlex Partner Medical Dictionary © Farlex 2012
malate dehydrogenaseAn oxidoreductase (EC 184.108.40.206) in mitochondria and the cytosol that catalyses the reversible NAD+/NADH reaction in the presence of S-malate, yielding oxaloacetate, a step in the citric acid cycle. Malate dehydrogenase is increased in myocardial infarction, hepatocellular necrosis, megaloblastic anaemia, and cancer.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
mal·ate de·hy·dro·gen·ase(mal'āt dē-hī'drō-jĕ-nās)
Any enzyme that catalyzes the dehydrogenation of malate to oxaloacetate. At least six are known; one is an enzyme in the tricarboxylic acid cycle.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012