pyruvate kinase


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Related to pyruvate kinase: pyruvate kinase deficiency

py·ru·vate ki·nase (PK),

phosphoenolpyruvate kinase; a phosphotransferase catalyzing transfer of phosphate from phosphoenolpyruvate to ADP, forming ATP and pyruvate; other nucleoside phosphates can participate in the reaction; a key step in glycolysis; a deficiency in pyruvate kinase will lead to hemolytic anemia.

pyruvate kinase

[pī′rəvāt]
an enzyme essential for anaerobic glycolysis in red blood cells. It catalyzes the transfer of a phosphate group from adenosine triphosphate to produce adenosine diphosphate.

py·ru·vate ki·nase

(PK) (pī'rū-vāt kī'nās)
A phosphotransferase catalyzing the transfer of phosphate from phosphoenolpyruvate to adenosine diphosphate, forming adenosine triphosphate and pyruvate; other nucleoside phosphates can participate in the reaction; a key step in glycolysis; pyruvate kinase deficiency leads to hemolytic anemia.

py·ru·vate ki·nase

(PK) (pī'rū-vāt kī'nās)
A phosphotransferase catalyzing the transfer of phosphate from phosphoenolpyruvate to adenosine diphosphate, forming adenosine triphosphate and pyruvate; other nucleoside phosphates can participate in the reaction; a key step in glycolysis; pyruvate kinase deficiency leads to hemolytic anemia.

pyruvate kinase (pīroo´vāt kī´nās´),

n an enzyme essential for anaerobic glycolysis in red blood cells.

pyruvate

a salt, ester or anion of pyruvic acid. The term is used interchangeably with pyruvic acid. Pyruvate is the end product of glycolysis and may be metabolized in the body to lactate or to acetyl CoA. In yeast it is metabolized to ethanol.

pyruvate carboxylase
an enzyme concerned in the conversion of pyruvate to oxaloacetic acid.
pyruvate dehydrogenase
actively concerned in the decarboxylation of pyruvate to acetyl CoA and CO2.
pyruvate kinase
a glycolytic pathway enzyme (called also PK) which catalyzes the formation of pyruvate from phosphoenolpyruvate (PEP). A deficiency of the enzyme is a hereditary defect in humans and occurs also in Beagle and Basenji dogs, causing a familial nonspherocytic anemia.
pyruvate transaminase
References in periodicals archive ?
The soluble protein in the hepatopancreas, glycogen in the hepatopancreas and muscle, and malate dehydrogenase (MDH), pyruvate kinase (PK), and glucose-6-phosphate dehydrogenase (G6PDH) activities of Litopenaeus vannamei fed experimental diets for 42 days.
In the presence of palmitic acid, mogrosides restored GLUT2 and pyruvate kinase expression possibly by reducing intracellular ROS, suggesting the possible involvement of oxidative stress induced by the FOXO1 activation pathway.
Caption: Figure 3: The assessment of the influence of ageing on adenylate kinase (a, b); creatine kinase (c, d); pyruvate kinase (e, f); and hexokinase (g, h) activities in myoblasts of passage 2 (P2) and passage 6 (P6).
Agios gets FDA orphan drug status for AG-348 to treat pyruvate kinase deficiency
The activities of hexokinase, pyruvate kinase and glucose-6-phosphate dehydrogenase were significantly decreased whereas the activities of lactate dehydrogenase.
Test results for hemolysis remained negative, and glucose 6-phosphate deshydrogenase and erythrocyte pyruvate kinase levels 6 months after transfusion were within normal limits.
It may be possible to design drugs that mildly suppress pyruvate kinase activity as a means of replicating the immune status of normal pregnancy," said Petty.
For the assessment of metabolic capacities and their effects on the reproductive cycle, we measured the glycolytic enzymes phosphoglucose isomerase (PGI), phosphomannose isomerase (PMI), pyruvate kinase (PK), one enzyme of protein metabolism (aspartate aminotransferase [AAT]), and the mitochondrial enzyme citrate synthase (CS) in the adductor muscle of scallops P.
G6PD and pyruvate kinase concentrations were within reference intervals, and a presumptive diagnosis of hereditary elliptocytosis was made.
For example, our previous study (Chan et at, 2011) demonstrated that baicalein could significantly reverse the ciprofloxacin resistance of MRSA possibly by inhibiting the NorA efflux pump in vitro and inhibition of a newly discovered MRSA specific pyruvate kinase (PK) (Zoraghi et al.
hexokinase (HK), glucose-6-phosphate isomerase (GPI), phospho-fructokinase (PFK), fructose-bisphosphate aldolase (FBA), triosphosphate isomerase (TIM), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphoglycerate kinase (PGK), phosphoglycerate mutase (IPGM), enolase and pyruvate kinase (PK) were isolated.

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