pyruvate kinase


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Related to pyruvate kinase: pyruvate kinase deficiency

py·ru·vate ki·nase (PK),

phosphoenolpyruvate kinase; a phosphotransferase catalyzing transfer of phosphate from phosphoenolpyruvate to ADP, forming ATP and pyruvate; other nucleoside phosphates can participate in the reaction; a key step in glycolysis; a deficiency in pyruvate kinase will lead to hemolytic anemia.

py·ru·vate ki·nase

(PK) (pī'rū-vāt kī'nās)
A phosphotransferase catalyzing the transfer of phosphate from phosphoenolpyruvate to adenosine diphosphate, forming adenosine triphosphate and pyruvate; other nucleoside phosphates can participate in the reaction; a key step in glycolysis; pyruvate kinase deficiency leads to hemolytic anemia.

py·ru·vate ki·nase

(PK) (pī'rū-vāt kī'nās)
A phosphotransferase catalyzing the transfer of phosphate from phosphoenolpyruvate to adenosine diphosphate, forming adenosine triphosphate and pyruvate; other nucleoside phosphates can participate in the reaction; a key step in glycolysis; pyruvate kinase deficiency leads to hemolytic anemia.
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Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase, phosphoenol pyruvate carboxykinase and GLUT4 translocation in experimental diabetic rats.
Effect of tangeretin, a polymethoxylated flavone on glucose metabolism in streptozotocin-induced diabetic rats
Two isoforms of pyruvate kinase (PfPK types I and II) are found in P.
Exploiting unique structural and functional properties of malarial glycolytic enzymes for antimalarial drug development
cDNAof GLUT2 and pyruvate kinase were analyzed using semi-quantitative PCR with Es Taq Mastermix (CoWin) and analyzed by 2% agarose gel electrophoresis and fluorescence gel image analysis using JS-780 Automatic Gel Imager (Shanghai Peiqing Science & Technology, China).
Antioxidant effect of mogrosides against oxidative stress induced by palmitic acid in mouse insulinoma NIT-1 cells
The activities of hexokinase and pyruvate kinase were reduced while the activities of glucose-6-phosphatase and fructosel, 6-bisphosphatase were increased in rats fed high fructose.
Insulin sensitizing actions of fenugreek seed polyphenols, quercetin & metformin in a rat model
The enzyme, pyruvate kinase, comes in two forms, but the research found that one, PKM2, enabled accelerated glucose consumption.
Enzyme linked to tumor growth
Pyruvate kinase deficiency: the genotype-phenotype association.
Pyruvate kinase deficiency in a South African kindred caused by a 1529A mutation in the PK-LR gene
By contrast, lactate is stable because, with enolase inhibited, no phosphoenolpyruvate is formed and thus there is no substrate for pyruvate kinase and there is no production of pyruvate or lactic acid.
Stabilization of glucose in blood specimens: mechanism of delay in fluoride inhibition of glycolysis
They found an enzyme called pyruvate kinase M2 gobbles up glucose to fuel the disease's spread.
Protein to hit cancer
Pyruvate kinase (ATP-pyruvate 2-O-phosphotransferase, EC 2.7.1.40, further denoted as PK) catalyses the final step of glycolysis, transferring the phosphoryl group from phosphoenolpyruvate (PEP) to ADP and producing pyruvate and ATP [1]:
Kinetic analysis of cooperativity of phosphorylated L-type pyruvate kinase/Fosforuleeritud L-tuupi puruvaadi kinaasi kooperatiivsuse kineetiline analuus
Experimental studies have shown that many glycolytic enzymes bind cytoskeletal proteins reversibly including lactate dehydrogenase (LDH), fructose-1,6-bisphosphate aldolase (aldolase), glyceraldehydes 3-phosphate dehydrogenase (GAPDH), 3-phosphoglycerate kinase, glucose isomerase, phosphofructokinase, and pyruvate kinase (3,4) and that the interaction may be electrostatic in nature (3).
Computer modeling of electrostatic interactions between LDH and actin
(1980) with an ATP-regenerating system consisting of phosphoenolpyruvate and pyruvate kinase. CK catalyzes the phosphorylation of glycocyamine, albeit at a much lower rate than creatine.
Functional and evolutionary implications of the distribution of phosphagens in primitive-type spermatozoa
Activities of two enzymes, citrate synthase (CS) and pyruvate kinase (PK), were determined by methods given in Choi et al.
Inverse relationship between functional maturity and exponential growth rate of avian skeletal muscle: a constraint on evolutionary response

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