pyruvate kinase


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Related to pyruvate kinase: pyruvate kinase deficiency

py·ru·vate ki·nase (PK),

phosphoenolpyruvate kinase; a phosphotransferase catalyzing transfer of phosphate from phosphoenolpyruvate to ADP, forming ATP and pyruvate; other nucleoside phosphates can participate in the reaction; a key step in glycolysis; a deficiency in pyruvate kinase will lead to hemolytic anemia.

pyruvate kinase

[pī′rəvāt]
an enzyme essential for anaerobic glycolysis in red blood cells. It catalyzes the transfer of a phosphate group from adenosine triphosphate to produce adenosine diphosphate.

py·ru·vate ki·nase

(PK) (pī'rū-vāt kī'nās)
A phosphotransferase catalyzing the transfer of phosphate from phosphoenolpyruvate to adenosine diphosphate, forming adenosine triphosphate and pyruvate; other nucleoside phosphates can participate in the reaction; a key step in glycolysis; pyruvate kinase deficiency leads to hemolytic anemia.

py·ru·vate ki·nase

(PK) (pī'rū-vāt kī'nās)
A phosphotransferase catalyzing the transfer of phosphate from phosphoenolpyruvate to adenosine diphosphate, forming adenosine triphosphate and pyruvate; other nucleoside phosphates can participate in the reaction; a key step in glycolysis; pyruvate kinase deficiency leads to hemolytic anemia.

pyruvate kinase (pīroo´vāt kī´nās´),

n an enzyme essential for anaerobic glycolysis in red blood cells.

pyruvate

a salt, ester or anion of pyruvic acid. The term is used interchangeably with pyruvic acid. Pyruvate is the end product of glycolysis and may be metabolized in the body to lactate or to acetyl CoA. In yeast it is metabolized to ethanol.
pyruvate carboxylase
an enzyme concerned in the conversion of pyruvate to oxaloacetic acid.
pyruvate dehydrogenase
actively concerned in the decarboxylation of pyruvate to acetyl CoA and CO2.
pyruvate kinase
a glycolytic pathway enzyme (called also PK) which catalyzes the formation of pyruvate from phosphoenolpyruvate (PEP). A deficiency of the enzyme is a hereditary defect in humans and occurs also in Beagle and Basenji dogs, causing a familial nonspherocytic anemia.
pyruvate transaminase
see alanine aminotransferase.
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References in periodicals archive ?
The soluble protein in the hepatopancreas, glycogen in the hepatopancreas and muscle, and malate dehydrogenase (MDH), pyruvate kinase (PK), and glucose-6-phosphate dehydrogenase (G6PDH) activities of Litopenaeus vannamei fed experimental diets for 42 days.
Growth, body composition, and ammonia tolerance of juvenile white shrimp Litopenaeus vannamei fed diets containing different carbohydrate levels at low salinity
In the presence of palmitic acid, mogrosides restored GLUT2 and pyruvate kinase expression possibly by reducing intracellular ROS, suggesting the possible involvement of oxidative stress induced by the FOXO1 activation pathway.
Antioxidant effect of mogrosides against oxidative stress induced by palmitic acid in mouse insulinoma NIT-1 cells
Structure and function of human erythrocyte pyruvate kinase.
Kinetic analysis of cooperativity of phosphorylated L-type pyruvate kinase/Fosforuleeritud L-tuupi puruvaadi kinaasi kooperatiivsuse kineetiline analuus
Caption: Figure 3: The assessment of the influence of ageing on adenylate kinase (a, b); creatine kinase (c, d); pyruvate kinase (e, f); and hexokinase (g, h) activities in myoblasts of passage 2 (P2) and passage 6 (P6).
Proliferation of Human Primary Myoblasts Is Associated with Altered Energy Metabolism in Dependence on Ageing In Vivo and In Vitro
Agios gets FDA orphan drug status for AG-348 to treat pyruvate kinase deficiency
US FDA grants orphan drug designation to Agios Pharmaceuticals' AG-348
The activities of hexokinase, pyruvate kinase and glucose-6-phosphate dehydrogenase were significantly decreased whereas the activities of lactate dehydrogenase.
Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats
Test results for hemolysis remained negative, and glucose 6-phosphate deshydrogenase and erythrocyte pyruvate kinase levels 6 months after transfusion were within normal limits.
Unusual transmission of plasmodium falciparum, Bordeaux, France, 2009
It may be possible to design drugs that mildly suppress pyruvate kinase activity as a means of replicating the immune status of normal pregnancy," said Petty.
Why autoimmune diseases go into remission during pregnancy
For the assessment of metabolic capacities and their effects on the reproductive cycle, we measured the glycolytic enzymes phosphoglucose isomerase (PGI), phosphomannose isomerase (PMI), pyruvate kinase (PK), one enzyme of protein metabolism (aspartate aminotransferase [AAT]), and the mitochondrial enzyme citrate synthase (CS) in the adductor muscle of scallops P.
Metabolic capacities and immunocompetence of sea scallops (Placopecten magellanicus, gmelin) at different ages and life stages
G6PD and pyruvate kinase concentrations were within reference intervals, and a presumptive diagnosis of hereditary elliptocytosis was made.
Hemoglobin Hagley Park: a novel ([alpha]82Ala[right arrow]Thr) substitution identified in an infant with severe hemolytic anemia
For example, our previous study (Chan et at, 2011) demonstrated that baicalein could significantly reverse the ciprofloxacin resistance of MRSA possibly by inhibiting the NorA efflux pump in vitro and inhibition of a newly discovered MRSA specific pyruvate kinase (PK) (Zoraghi et al.
Synergistic effects of diosmetin with erythromycin against ABC transporter over-expressed methicillin-resistant Staphylococcus aureus (MRSA) RN4220/pUL5054 and inhibition of MRSA pyruvate kinase
hexokinase (HK), glucose-6-phosphate isomerase (GPI), phospho-fructokinase (PFK), fructose-bisphosphate aldolase (FBA), triosphosphate isomerase (TIM), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphoglycerate kinase (PGK), phosphoglycerate mutase (IPGM), enolase and pyruvate kinase (PK) were isolated.
Analysis of functional genes in carbohydrate metabolic pathway of anaerobic rumen fungus Neocallimastix frontalis PMA02

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