pyruvate dehydrogenase (lipoamide)

(redirected from pyruvate dehydrogenase lipoamide)

py·ru·vate de·hy·dro·gen·ase (lip·o·am·ide)

an oxidoreductase catalyzing conversion of pyruvate and (oxidized) lipoamide to CO2 and S6-acetyldihydrolipoamide in two successive reactions: the first between pyruvate and thiamin pyrophosphate to yield CO2 and α-hydroxyethylthiamin pyrophosphate (active pyruvate); the second between the last named and lipoamide to regain the thiamin pyrophosphate and yield S6-acetylhydrolipoamide. Compare: α-ketodecarboxylase.
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References in periodicals archive ?
In that study 3 SNPs in creatine kinase, muscle (CKM), pyruvate dehydrogenase lipoamide kinase isozyme 4 (PDK4) and cytochrome c oxidase, subunit 4, isoform 2 (COX4I2) genotype frequency distributions were significantly (P<0.05) different between elite and non-elite thoroughbred racehorses.

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