Structures of the human pyruvate dehydrogenase
complex cores: a highly conserved catalytic center with flexible N-terminal domains.
Differing roles of pyruvate dehydrogenase
kinases during mouse oocyte maturation.
Sapcariu et al., "Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase
for the synthesis of Itaconate and to enable cytokine expression," The Journal of Biological Chemistry, vol.
Tsai, "Induction of pyruvate dehydrogenase
kinase-3 by hypoxiainducible factor-1 promotes metabolic switch and drug resistance," The Journal of Biological Chemistry, vol.
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase
Dang, "Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase
kinase 1," Molecular and Cellular Biology, vol.
It is known that HIF1 induces the glucose transporter (GLUT), pyruvate dehydrogenase
kinase 1, lactate dehydrogenase A, and hexokinase expression [20-26].
, a-ketoglutarate dehydrogenase (Bergquist et al.
Two separate IPG were purified from rat liver: one (containing DCI and galactosamine) was able to activate pyruvate dehydrogenase
phosphatase and the second (containing MI and glucosamine) was able to inhibit cyclic adenosine monophosphate (cAMP) kinase and adenylate cyclase, both regulatory enzymes in FFA metabolism .
(15) Increased levels of proinflammatory cytokine by IAV infection, such as tumor necrosis factor (TNF)-o, interleukin (IL) 6, and IL-1[beta] (i.e., cytokine storm), suppresses mitochondrial energy homeostasis through up-regulation of pyruvate dehydrogenase
kinase (PDK)-4 in various organs with the exception of the brain.
The LBE treated cells showed a specific increase in expression of PPAR target gene expression, including fatty acid binding protein 4, fatty acid transport protein 4, CD36 molecule, pyruvate dehydrogenase
kinase 4, liver X receptor alpha and lipogenic stearoyl-CoA desaturase.
Insulin stimulates glycolysis by activating the rate limiting enzymes, phosphofructokinase and pyruvate dehydrogenase