pyruvate dehydrogenase


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py·ru·vate de·hy·dro·gen·ase

a structurally distinct collection of enzymes containing pyruvate dehydrogenase (lipoamide), dihydrolipoyl transacetylase, and dihydrolipoyl dehydrogenase.

pyruvate dehydrogenase

(1) Puruvate dehydrogenase (cytochrome), EC 1.2.2.2 (a deleted enzyme name, now covered by pyruvate dehydrogenase (quinone), EC 1.2.5.1).
(2) Pyruvate dehydrogenase (acetyl-transferring), EC 1.2.4.1.
References in periodicals archive ?
Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains.
Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation.
Sapcariu et al., "Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of Itaconate and to enable cytokine expression," The Journal of Biological Chemistry, vol.
Tsai, "Induction of pyruvate dehydrogenase kinase-3 by hypoxiainducible factor-1 promotes metabolic switch and drug resistance," The Journal of Biological Chemistry, vol.
Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex.
Dang, "Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1," Molecular and Cellular Biology, vol.
It is known that HIF1 induces the glucose transporter (GLUT), pyruvate dehydrogenase kinase 1, lactate dehydrogenase A, and hexokinase expression [20-26].
Two separate IPG were purified from rat liver: one (containing DCI and galactosamine) was able to activate pyruvate dehydrogenase phosphatase and the second (containing MI and glucosamine) was able to inhibit cyclic adenosine monophosphate (cAMP) kinase and adenylate cyclase, both regulatory enzymes in FFA metabolism [47].
(15) Increased levels of proinflammatory cytokine by IAV infection, such as tumor necrosis factor (TNF)-o, interleukin (IL) 6, and IL-1[beta] (i.e., cytokine storm), suppresses mitochondrial energy homeostasis through up-regulation of pyruvate dehydrogenase kinase (PDK)-4 in various organs with the exception of the brain.
The LBE treated cells showed a specific increase in expression of PPAR target gene expression, including fatty acid binding protein 4, fatty acid transport protein 4, CD36 molecule, pyruvate dehydrogenase kinase 4, liver X receptor alpha and lipogenic stearoyl-CoA desaturase.
Insulin stimulates glycolysis by activating the rate limiting enzymes, phosphofructokinase and pyruvate dehydrogenase [6].