pyruvate carboxylase


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Related to pyruvate carboxylase: gluconeogenesis

py·ru·vate car·box·yl·ase

ligase catalyzing reaction of ATP, pyruvate, and HCO32-, to form ADP, orthophosphate, and oxaloacetate; biotin and acetyl-CoA are involved; an absence of this enzyme results in neuronal loss in the cerebral cortex, leading to mental retardation.
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(1997) Pyruvate carboxylase as an anaplerotic enzyme in Corynebacterium glutamicum, Microbiology-Uk 143: 1095-1103.
Feed restriction induces pyruvate carboxylase but not phosphoenolpyruvate carboxykinase in dairy cows.
Another noticeable finding is the higher expression of pyruvate carboxylase (PC) by rat beta cells.
Furthermore, an increase in pyruvate carboxylase (PC) activity is evident under glutamate-overproducing conditions, which may lead to an increase in carbon flux from pyruvate to oxaloacetate.
Abbreviations: DTT, dithiothreitol; MCS, multipurpose cryogenic surface; PEPCase, phosphoenol pyruvate carboxylase; Rubisco, ribulose-1,5-bisphosphate carboxylase; SDS-PAGE, sodium dodecyl sulfate polyacrylaminde gel eclectrophoresis.
Liver samples (200 mg) were prepared for pyruvate carboxylase, phosphoenolpyruvate carboxykinase (PEPCK), peroxisome proliferators activated receptor-[alpha] (PPAR-[alpha]), and glucose transporter-2 (GLUT-2).