pyruvate


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pyruvate

 [pi´roo-vāt]
a salt, ester, or anion of pyruvic acid. Pyruvate is the end product of glycolysis and may be metabolized to lactate or to acetyl CoA.

py·ru·vate (Pyr),

(pī'rū-vāt),
A salt or ester of pyruvic acid.

pyruvate

(pī-ro͞o′vāt, pĭ-)
n.
A salt or an ester of pyruvic acid.

py·ru·vate

(pī'rū-vāt)
A salt or ester of pyruvic acid.
Pyruvic acidclick for a larger image
Fig. 264 Pyruvic acid . Molecular structure.

pyruvic acid

or

pyruvate

an important 3-carbon molecule formed from GLUCOSE and GLYCEROL in glycolysis (see Fig. 264 ). See also ACETYLCOENZYME A. Pyruvic acid is broken down further, the precise reactions depending upon whether oxygen is present or not. See AEROBIC RESPIRATION, ANAEROBIC RESPIRATION.
References in periodicals archive ?
The spectrum of pyruvate dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients.
Alanine enters the gluconeogenic pathway through transamination with alfa-ketoglutarate catalyzed by alanine amino transferase, yielding pyruvate and glutamate, respectively.
One-way analysis of variance (ANOVA) followed by Fisher's least significant difference post hoc test was used to analyze changes in hippocampal glucose, lactate, pyruvate, and glutamate levels.
The corresponding hyperpolarized [sup.13]C spectra from the same animal (Figure 2(b)) demonstrated the spatial distribution of high [sup.13]C-labeled lactate and pyruvate signals over the entire brainstem region.
Therapeutic potential of pyruvate therapy for mitochondrial diseases.
The researchers decided to examine whether genetically diminishing the entry of pyruvate into the mitochondria would force hair follicle stem cells to make more lactate, and if that would activate the cells and grow hair more quickly.
We also found that pika LDH-C4 has an affinity for pyruvate that is 90-fold higher than that for lactate in our prevoious study, and it was beneficial to catalyze the conversion of pyruvate to lactate even at high concentration of lactate in our previous study (Wang et al., 2016).
Myc also induces LDH-A activation (for conversion of cytosolic pyruvate into lactate).
Lactate can be metabolized by various cells and tissues, for example, liver, germ cells, and neurons, converting to pyruvate via LDH and subsequently to glycogen or carbon dioxide [22].
With the exception of pyruvate and lactate, all test compounds induced a significant stimulation of insulin secretion when compared to the preperifusion phase with basal medium (Table 1).
In the second experimental study, glycine, sodium pyruvate, and resveratrol (Sigma-Aldrich, St.