Kinase Deficiency and Genetic Background
The spectrum of pyruvate
dehydrogenase complex deficiency: clinical, biochemical and genetic features in 371 patients.
Alanine enters the gluconeogenic pathway through transamination with alfa-ketoglutarate catalyzed by alanine amino transferase, yielding pyruvate
and glutamate, respectively.
One-way analysis of variance (ANOVA) followed by Fisher's least significant difference post hoc test was used to analyze changes in hippocampal glucose, lactate, pyruvate
, and glutamate levels.
The corresponding hyperpolarized [sup.13]C spectra from the same animal (Figure 2(b)) demonstrated the spatial distribution of high [sup.13]C-labeled lactate and pyruvate
signals over the entire brainstem region.
Therapeutic potential of pyruvate
therapy for mitochondrial diseases.
The researchers decided to examine whether genetically diminishing the entry of pyruvate
into the mitochondria would force hair follicle stem cells to make more lactate, and if that would activate the cells and grow hair more quickly.
We also found that pika LDH-C4 has an affinity for pyruvate
that is 90-fold higher than that for lactate in our prevoious study, and it was beneficial to catalyze the conversion of pyruvate
to lactate even at high concentration of lactate in our previous study (Wang et al., 2016).
Myc also induces LDH-A activation (for conversion of cytosolic pyruvate
Lactate can be metabolized by various cells and tissues, for example, liver, germ cells, and neurons, converting to pyruvate
via LDH and subsequently to glycogen or carbon dioxide .
With the exception of pyruvate
and lactate, all test compounds induced a significant stimulation of insulin secretion when compared to the preperifusion phase with basal medium (Table 1).
In the second experimental study, glycine, sodium pyruvate
, and resveratrol (Sigma-Aldrich, St.