Based on test type, the market has been segmented into MAT test, LAL test, rabbit pyrogen test
, and others.
There is a range of tests available for detecting endotoxins including the Rabbit Pyrogen Test
(RPT) and tests based on Limulus Amebocyte Lysate (LAL), which is derived from the blood cells of the horseshoe crab.
Evaluation of purified LPS pyrogen activity by rabbit pyrogen test
Dept of Transportation now accepts the Corrositex assay for corrosion testing, and the Bacterial Endotoxins Test replaces many instances of the rabbit pyrogen test
(MIVT:OTCBB), Vancouver, has announced that its proprietary Hydroxyapatite (HAp) ultra-thin "passive" stent coating has successfully passed the Rabbit Pyrogen Test
(Material Mediated) - ISO confirming that the coating is non- pyrogenic and does not induce fever.
Six alternative cellular assays have therefore been developed to replace the rabbit pyrogen test
and close the safety gap presented by use of the LAL test in controlling parenterals.
Scanner, Spectarophotometer, Dissolution Test Apparatus, Sterility and Pyrogen test
facilities and team of qualified experienced staff can handle testing of raw materials and finished products.
The three tests commonly used to measure pyrogenicity are the in vivo rabbit pyrogen test
(RPT), in vivo Limulus amoebocyte lysate (LAL) assay, and the in vitro monocyte activation test (MAT).
The traditional methods for pyrogen detection either require animal sacrifice for the Rabbit Pyrogen Test
(RPT), or are limited to the detection of endotoxin LPS from the cell walls of gram-negative bacteria (for example in the Limulus Amoebocyte Lysat [LAL] test).
Getting the pyrogen test
accepted by ISO is a matter of defining the results the test needs to show, as well as the availability and suitability of test materials.
In this report, the pyrogen testing market is categorized into three test segments in vitro pyrogen test
, LAL (Limulus amebocyte lysate) test, and rabbit test.
In vitro pyrogen tests
were developed more than twenty years ago with the main aim of ensuring that batches of injectable medication are not contaminated with feverprovoking substances.