pyrogen test

pyrogen test

An obsolete test of the adequacy of the hypothalamic-adenohypophysis-adrenocortical axis, in which timed doses of bacterial pyrogen evoke an increase in plasma cortisol in normal subjects.
References in periodicals archive ?
Getting the pyrogen test accepted by ISO is a matter of defining the results the test needs to show, as well as the availability and suitability of test materials.
In this report, the pyrogen testing market is categorized into three test segments in vitro pyrogen test, LAL (Limulus amebocyte lysate) test, and rabbit test.
There is a range of tests available for detecting endotoxins including the Rabbit Pyrogen Test (RPT) and tests based on Limulus Amebocyte Lysate (LAL), which is derived from the blood cells of the horseshoe crab.
Dept of Transportation now accepts the Corrositex assay for corrosion testing, and the Bacterial Endotoxins Test replaces many instances of the rabbit pyrogen test.
MIVT:OTCBB), Vancouver, has announced that its proprietary Hydroxyapatite (HAp) ultra-thin "passive" stent coating has successfully passed the Rabbit Pyrogen Test (Material Mediated) - ISO confirming that the coating is non- pyrogenic and does not induce fever.
Six alternative cellular assays have therefore been developed to replace the rabbit pyrogen test and close the safety gap presented by use of the LAL test in controlling parenterals.
Scanner, Spectarophotometer, Dissolution Test Apparatus, Sterility and Pyrogen test facilities and team of qualified experienced staff can handle testing of raw materials and finished products.
The traditional methods for pyrogen detection either require animal sacrifice for the Rabbit Pyrogen Test (RPT), or are limited to the detection of endotoxin LPS from the cell walls of gram-negative bacteria (for example in the Limulus Amoebocyte Lysat [LAL] test).
Detection of pyrogens adsorbed to intraocular lenses: evaluation of limulus amoebocyte lysate and in vitro pyrogen tests.
Comparison and validation of novel pyrogen tests based on the human fever reaction.
Recent regulatory development initiatives to ban animal testing for cosmetics in Guatemala and Australia are promising as well as the revision of the US Pharmacopeia to include in vitro pyrogen tests which can replace respective tests in rabbits.