pyrogen


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Related to pyrogen: endotoxin, endogenous pyrogen

pyrogen

 [pi´ro-jen]
an agent that causes fever; called also pyretic and pyrectic. adj., adj pyrogen´ic.
endogenous pyrogen a low-molecular-weight protein that is produced by phagocytic leukocytes in response to stimulation by exogenous pyrogens and released into the circulation; it induces fever by acting on the preoptic area of the hypothalamus to raise the set-point of the hypothalamic thermostat. The pyrogen produced by monocytes and macrophages is not identical to that produced by neutrophils and eosinophils; the mononuclear phagocytes also produce a greater amount of pyrogen for a longer period of time than do the polymorphonuclear cells.
exogenous p's fever-producing agents of external origin, e.g., bacterial endotoxins and other microbial products, antigen-antibody complexes, viruses and synthetic polynucleotides, incompatible blood and blood products, and androgen breakdown products such as etiocholanolone; the action is mediated by endogenous pyrogen.

py·ro·gen

(pī'rō-jen),
A fever-inducing agent; pyrogens are produced by bacteria, molds, viruses, and yeasts.
[pyro- + G. -gen, producing]

pyrogen

(pī′rə-jən)
n.
A substance that produces fever.

pyrogen

 A fever-inducing substance

py·ro·gen

(pī'rō-jen)
A fever-inducing agent; produced by bacteria, molds, viruses, and yeasts; commonly found in distilled water.
[pyro- + G. -gen, producing]

pyrogen

Any substance that causes fever. Endogenous pyrogens are proteins, such as interleukin-1, released by white blood cells in response to bacterial or viral infections. These act on the temperature-regulating centre in the brain, effectively resetting the thermostat at a higher level and causing the muscles to contract repeatedly and rapidly (shivering) so as to raise body temperature.

pyrogen

any substance which alters the body thermostat of HOMOIOTHERMS to a higher setting, giving rise to fever.

Pyrogen

A chemical circulating in the blood that causes a rise in body temperature.
Mentioned in: Fever

py·ro·gen

(pī'rō-jen)
Fever-inducing agent; produced by bacteria, molds, viruses, and yeasts.
[pyro- + G. -gen, producing]
References in periodicals archive ?
There is a dose-dependent febrile response in the rabbit pyrogen test when polyinosinic:polycytidylic acid [poly(I * C)], an immunostimulant, is administered intravenously.
These data implicate not just nickel salts, but any fine particulate metal, as a potential medical device pyrogen. There is a large volume of research reports describing metal particulates inducing cytokine upregulation.
The pyrogen concentration in the sample is then determined from the IL-1B concentration via an endotoxin standard curve, and analyzed with the PyroDetect data analysis tool.
The broad pyrogen spectrum detected by the PyroDetect system was evaluated against a set of substances.
The Pyrogen Test was designed to determine the presence of chemical pyrogens in extracts of solid materials in order to limit risks of febrile reaction in a patient.
Technique Impurities most effectively removed Distillation inorganic ions, particles, bacteria, pyrogens Reverse osmosis particles, bacteria, pyrogens Deionization inorganic ions and dissolved gases Filtration particles and bacteria Ultrafiltration (UF) particles, bacteria, pyrogens Adsorption organics and chlorine Ultraviolet (UV) organics and bacteria oxidation Combination UV/UF organics, particles, bacteria, pyrogens and nucleases Table 1: Impurities removed by each technology With the ability to produce the highest grade of pure water, combined UV/UF effectively removes all impurities, and is the only point-of-use technique able to eliminate problematic nucleases.
Pyrogen testing is carried out at all levels of pharmaceutical and biopharmaceutical manufacturing process to minimize the risk of product contamination.
The highest predominant serogroup in vaccinated canine for 1:100 titre was grippotyphosa and icterohaemorrhagiae followed by canicola, pomona, autumnalis and pyrogenes. For 1:200 titres highest prevalent serogroup was canicola followed by pomona, autumnalis, icterohaemorrhagiae and pyrogens.
The stills consistently produce high-quality ASTM Type II water and remove inorganic ions, dissolved gasses, organics, particles, bacteria, pyrogens and nucleases from water.
Fevers are caused by chemicals called pyrogens flowing in the bloodstream.
It effectively removes most inorganic solids, all organics with a boiling point greater than water, and virtually all bacteria and pyrogens. Pyrogens are lipopolysaccharides found in the outer cell walls of certain bacteria.
POD dispensers can be adapted with contaminant-specific final polishers to remove pyrogens, nucleases, bacteria, particulates and organics.