Increased expression of the NOD-like receptor family,
pyrin domain containing 3 inflammasome in dermatomyositis and polymyositis is a potential contributor to their pathogenesis.
For example, although it was not detected by GWASs, a SNP in the 3'-UTR of NLR family,
pyrin domain containing 3 (NLRP3), which controls the activation of inflammatory caspase-1 by forming NLRP3-inflammasomes, was found to be significantly associated with susceptibility to Japanese food-induced anaphylaxis.
The mutations, on MEFV gene encoding
pyrin protein, are thought to be the cause of FMF.
4] The Mediterranean Fever (MEFV) gene, associated with FMF, is located on chromosome 16 and encodes a 781-amino-acid protein termed
pyrin.
The potential mechanism maybe that allopurinol inhibit p38 MAPK/ NOD-like receptor
pyrin domain-containing 3 inflammasome pathway activation (Wang et al.
Nanoparticles activate the NLR
pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1 [alpha] and IL-1[beta].
7] The largest group contains 14 members which have N-terminal
pyrin domain (PYD).
Cryopyrinopathies are genetically determined diseases caused by mutations in NLRP3 (NLR family,
pyrin domain containing 3) that manifest by cold-induced urticaria, periodic fever, and arthritis.
The protein encoded by MEFV gene has been named
pyrin for its role in anti-pyrexia.
Activation of the
pyrin inflammasome by intracellular Burkholderia cenocepacia," Journal of Immunology, vol.
Interestingly, the main pathways involved in cellular senescence regulation, such as the NF-[kappa]B, the mechanistic target of rapamycin (mTOR), and the interleukin-1/NLR family
pyrin domain containing 3 (IL-1/NLRP3) inflammasome pathways, are master modulators of the aging rate [27-29].
Other stories to feature include the rescues of the HMHS Rohilla in 1914, SS Glenravel in 1915, the Ponus in 1916, the SS Alondra in 1916 and the
Pyrin and Fernebo in 1917.
