7,8) There are data in the literature which support that pyrin
protein encoded by MEFV gene takes a role in the intracellular control of inflammation.
Mutated forms of pyrin
are frequently found in familial Mediterranean fever (FMF) patients.
In addition to CD27, Siva-1 can interact with the peroxisomal membrane protein (PMP22) (4), tyrosine kinase 2 (Tyk2) (5), pyrin
(6), lysophosphatidic acid receptor 2 (LPA2) (7), the CVB3 capsid protein VP2 (8), and CD4 (9).
ASC is a protein comprised of an N-terminal Pyrin
domain and a C-terminal CARD domain (Richards et al.
Using different mouse models of inflammasome deficiency, such as mice deficient in Asc (apoptosis-associated speck-like protein containing a caspase recruitment domain), NLRP3 (nucleotide-binding domain, leucine rich family, pyrin
containing 3), caspase, or interleukin 18, the authors showed significant alterations in gut microbiota as evidenced by increased members of Bacteriodetes and decreased members of Firmicutes in these mouse models.
FMF is caused by mutations in the MEFV gene which encodes the anti-inflammatory pyrin
4 in several ethnic groups, (17-19) with the subsequent identification of the causative gene, NLRP7 (nucleotide-binding, leucine-rich repeat, pyrin
Bu genin kodladigi pyrin
ozellikle notrofillerde bulunan proinflamatuar mediator-leri azaltma ozelligine sahiptir.
5,6) When nonsense or missense mutations in the MEFV gene occur, pyrin
becomes either mutated or not produced.
It is approximately 10 kilobases, with 10 exons expressing a transcript coding a 781-amino-acid protein known as pyrin
, or marenostrin.
The researchers theorize that normal pyrin
shuts off inflammation, the body's response to infection that results in fever, swelling, and pain.
is expressed mainly in granulocytes and is thought to be a negative regulator of inflammation.