pyrimidine dimer


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py·rim·i·dine di·mer

a product of ultraviolet radiation of pyrimidines in nucleic acids; most frequently thymidine dimers.
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Thus a single pyrimidine dimer, if left unrepaired, is sufficient to completely eliminate the expression of a transcriptional unit.
Simultaneous establishment of monoclonal antibodies specific for either cyclobutane pyrimidine dimer or (6-4) photoproduct from the same mouse immunized with ultraviolet-irradiated DNA.
DNA was obtained from plants that were not exposed to UV, with the following exceptions: pea seedlings from the greenhouse, soybean leaves from field-grown plants, and rice seedlings exposed to UV in the laboratory for measurement of pyrimidine dimer induction.
Ultraviolet radiation disrupts the structure of DNA by causing a chemical reaction that hooks together two distinct bases, forming a so-called pyrimidine dimer.
Specifically, niacinamide is known to enhance DNA excision repair and repair of UVB-induced cyclobutane pyrimidine dimers and UVA-induced 8-oxo-7,8-dihydro-2'-deoxyguanosine.
Scientists found that Polypodium leucotomos, orally administered to hairless mice before UV radiation, inhibited DNA damage, activated p53, increased removal of cyclobutane pyrimidine dimers, and reduced the number of 8-hydroxy-2'-deoxyguanosinepositive (8-OH-dG+) cells, which are markers of early DNA damage.
UVB and UVC light induce the formation of cyclobutane pyrimidine dimers (CPDs) and pyrimidine(6-4)pyrimidone photoproducts (6-4 PPs), whereas UVA light primarily causes oxidative DNA damage via the formation of 8-oxo-7,8-dihydroguanine (8-oxoG) and cyclobutane thymidine dimers [5, 6], potentially leading to single-strand breaks and other interstrand cross-links (ICLs) in DNA [7].
Reagentas cyclobutane pyrimidine dimers determination after UV-irradiation preliminary points to 1 Coll .
Further studies, performed mainly at Stanford University, revealed that the phage T4 enzymes specifically and uniquely incise DNA containing photoproducts called pyrimidine dimers.
14 T4 endonuclease V has been shown to repair cyclobutane pyrimidine dimers resulting from DNA damage.