pyrimidine 5'-nucleotidase

py·rim·i·dine 5'-nu·cle·o·ti·dase

an enzyme that catalyzes the hydrolysis of a pyrimidine-nucleoside 5'-monophosphate to produce orthophosphate and the pyrimidine nucleoside; a deficiency of this enzyme results in accumulation of pyrimidine nucleotides leading to hemolytic anemia.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Agapidou et al.'s case of pyrimidine 5'-nucleotidase deficiency and heterozygous [alpha]-thalassemia was an interesting co-existence (1).
Co-Existence of Hereditary Pyrimidine 5'-Nucleotidase Deficiency and Heterozygous a-Thalassemia: A Case Presentation.
A case of hemolytic anemia due to erythrocyte pyrimidine 5'-nucleotidase deficiency.
Detection of pyrimidine 5'-nucleotidase deficiency using [sup.1]H or [sup.31]P nuclear magnetic resonance.
Lead inhibits heme biosynthesis and causes anemia, basophilic stippling, a decline in red cell 8-aminolevulinic acid dehydrogenase, and an increase in urinary 8-aminolevulinic acid, urinary coproporphyrin, red cell zinc protoporphyrin (ZPP), and pyrimidine 5'-nucleotidase (12).