pyrimidine 5'-nucleotidase

py·rim·i·dine 5'-nu·cle·o·ti·dase

an enzyme that catalyzes the hydrolysis of a pyrimidine-nucleoside 5'-monophosphate to produce orthophosphate and the pyrimidine nucleoside; a deficiency of this enzyme results in accumulation of pyrimidine nucleotides leading to hemolytic anemia.

References in periodicals archive ?

s case of pyrimidine 5'-nucleotidase deficiency and heterozygous [alpha]-thalassemia was an interesting co-existence (1).

We also reported a family with severe hereditary pyrimidine 5'-nucleotidase deficiency; in addition, 3 other families were also mentioned (2).

Co-Existence of Hereditary Pyrimidine 5'-Nucleotidase Deficiency and Heterozygous a-Thalassemia: A Case Presentation.

A case of hemolytic anemia due to erythrocyte pyrimidine 5'-nucleotidase deficiency.

About pyrimidine 5'-nucleotidase deficiency / Pirimidin 5'nukleotidaz noksanligi hakkinda

Detection of pyrimidine 5'-nucleotidase deficiency using [sup.

[sup.1]H-NMR spectroscopy of body fluids: inborn errors of purine and pyrimidine metabolism

Lead inhibits heme biosynthesis and causes anemia, basophilic stippling, a decline in red cell 8-aminolevulinic acid dehydrogenase, and an increase in urinary 8-aminolevulinic acid, urinary coproporphyrin, red cell zinc protoporphyrin (ZPP), and pyrimidine 5'-nucleotidase (12).

Predictive value of determinations of zinc protoporphyrin for increased blood lead concentrations