Elimban, "Mechanisms of the beneficial effects of vitamin B6 and pyridoxal 5-phosphate
on cardiac performance in ischemic heart disease," Clinical Chemistry and Laboratory Medicine, vol.
TABLE Consider these alternatives for neuropathic pain (2-12] Intervention Dose Adverse effects/special considerations Acetyl-L-carnitine 2000-3000 mg/d Nausea, vomiting; urine, breath, and sweat may have fishy odor Avoid use in patients taking warfarin Alpha lipoic acid 600 mg/d Nausea, vomiting, skin rash Possible injection site reaction with IV administration ALA/Rx combination ALA 100 mg bid + Nausea, vomiting pregabalin 75 mg bid + methylcobalamin 750 meg bid B vitamins Benfotiamine 100 mg qid Nausea, vomiting OR B1 25 mg OR benfotiamine 320 mg + B6 50-720 mg + B121000 meg/d OR L-methylfolate 3 mg + pyridoxal 5-phosphate
35 mg + methylcobalamin 2 mg bid Capsaicin Topical 0.
Pyridoxamine is a specialized form of vitamin B6 easily converted in the body to pyridoxal 5-phosphate
(PLP), the active form of the vitamin.
6] status was determined by direct measurement of thiamin diphosphate (TDP), FAD, and pyridoxal 5-phosphate
(PLP) in plasma, whole blood, or erythrocytes (1, 3, 15,16).
Homogeneous, nonradioactive, enzymatic assay for plasma pyridoxal 5-phosphate
The chemicals used were L-cysteine, D,L-homocysteine, L-methionine, adenosine (ADO), L-dithiothreitol, Triton X-100, pyridoxal 5-phosphate
, and potassium ferricyanide and were purchased from Sigma Chemical Co.
Pyridoxine reduces cholesterol and low-density lipoprotein and increases antithrombin III activity in 80-year-old men with low plasma pyridoxal 5-phosphate