pyridinoline cross-link

pyridinoline cross-link

collagen degradation marker found to be increased in urine in the setting of Raynaud phenomenon and systemic sclerosis (scleroderma). Reflects alterations in collagen turnover; may be useful in monitoring ongoing fibrosis in systemic sclerosis.
References in periodicals archive ?
Serum Vitamin D and Pyridinoline Cross-Linked Carboxyterminal Telopeptide of Type I Collagen in Patients with Ankylosing Spondylitis.
Urinary pyridinoline cross-links in Ehlers-Danlos syndrome type VI.
The number of pyridinoline cross-links and Hyl residues was expressed per collagenmolecule assuming 300 hydroxyproline residues per triple helix.
Such findings were then expressed in terms of peak ratios, with larger ratios reflecting an increase in the size and maturity of the crystals and an increase in the pyridinoline cross-links in collagen, both of which reflect a deterioration in the quality of the bone matrix, Dr.
The only study investigating the influence of the perimenopausal status on urinary pyridinoline cross-links excretion reported no differences between premenopausal women and perimenopausal women (36).
Radioimmunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen: a new serum marker of bone collagen degradation.
Serum C-terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP) Free y-carboxy glutamic acid TRAP Urine Calcium Hydroxyproline (total, free) Pyr (free, total) Dpd (free, total) NTx C-telopeptide (ICTP) Hydroxylysine glycosides Table 2.
Urinary excretion of pyridinoline cross-links correlates with bone turnover measured on iliac crest biopsy in patients with vertebrae osteoporosis.
The carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen in serum as a marker of bone resorption: the effect of nandrolone decanoate and hormone replacement therapy.
An initial immunoassay for pyridinoline cross-links, using polyclonal antiserum that recognized the free form of both DPD and pyridinoline, revealed increased urinary concentrations of the crosslink compounds in metabolic osteopathies but did not provide tissue-specific information and therefore lacked clinical specificity (29).
Multiple molecular forms of pyridinoline cross-links excreted in human urine evaluated by chromatographic and immunoassay methods.