pyridinoline cross-link

pyridinoline cross-link

collagen degradation marker found to be increased in urine in the setting of Raynaud phenomenon and systemic sclerosis (scleroderma). Reflects alterations in collagen turnover; may be useful in monitoring ongoing fibrosis in systemic sclerosis.
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Such findings were then expressed in terms of peak ratios, with larger ratios reflecting an increase in the size and maturity of the crystals and an increase in the pyridinoline cross-links in collagen, both of which reflect a deterioration in the quality of the bone matrix, Dr.
The only study investigating the influence of the perimenopausal status on urinary pyridinoline cross-links excretion reported no differences between premenopausal women and perimenopausal women (36).
Comparison of biochemical markers of bone turnover in Paget disease treated with pamidronate and a proposed model for the relationships between measurements of the different forms of pyridinoline cross-links.
Urinary excretion of pyridinoline cross-links correlates with bone turnover measured on iliac crest biopsy in patients with vertebrae osteoporosis.
An initial immunoassay for pyridinoline cross-links, using polyclonal antiserum that recognized the free form of both DPD and pyridinoline, revealed increased urinary concentrations of the crosslink compounds in metabolic osteopathies but did not provide tissue-specific information and therefore lacked clinical specificity (29).
Multiple molecular forms of pyridinoline cross-links excreted in human urine evaluated by chromatographic and immunoassay methods.