Comparison of biochemical markers of bone turnover in Paget disease treated with pamidronate and a proposed model for the relationships between measurements of the different forms of pyridinoline
total serum alkaline phosphatase; urinary pyridinoline
6 The recommended laboratory test to diagnose ky-phoscoliosis type of Ehlers-Danlos syndrome is the measurement of total urinary hydroxylvsyl pyridinoline
") and lysyl pyridinoline
("Deoxypyridinoline") crosslinks after hydrolysis by HPLC, a test with very high degree of sensitivity and specificity.
(pyr) and deoxypyridinoline (dpyr) are the two nonreducible pyridinium cross-links present in the mature form of collagen.
It will be important to document that the amino-terminal peptide of collagen cross-links (NTX), pyridinoline
(PYD), or deoxypyridinoline (DPD) perform as well when subjected to such rigorous study.
We recently reported (8) that the (3-CrossLaps assay for serum Cterminal telopeptide of type I collagen ([beta]-CTX) (9-11) provides values that are no less significant than those for pyridinoline
(PYD) and deoxypyridinoline (DPD), 2 commonly used serum bone resorption markers, in assessing bone metabolism in HD patients.
The least significant change amounts for bone alkaline phosphatase (AP), osteocalcin, pyridinoline
, deoxypyridinoline, and N-telopeptide are in the range of 15% to 40% (20).
Specific degradation products of the bone matrix, such as DPD and pyridinoline
(PYD), closely reflect the rate of bone metabolism.