pyridinoline


Also found in: Acronyms.

pyr·i·din·o·line

(pir'i-din'ō-lēn),
Hydroxypyridinium; a breakdown product of bone collagen, assayed, as is pyridinium (q.v.), to gauge osteoclastic activity.

py·ri·din·o·line

(pir'i-din'ŏ-lēn)
Hydroxypyridinium; a breakdown product of bone collagen, assayed (as is pyridinium) to measure osteoclastic activity.
References in periodicals archive ?
Giannobile, "C-telopeptide pyridinoline cross-links.
total serum alkaline phosphatase; urinary pyridinoline
The pyridinium crosslinks formed (deoxypyridinoline or Dpd, and pyridinoline or Pyd) act to strengthen the matrix, and are only found in mature collagen.
Assessment and recommendations of factors contributing to preanalytical variability of urinary pyridinoline and deoxypyridinoline.
Such findings were then expressed in terms of peak ratios, with larger ratios reflecting an increase in the size and maturity of the crystals and an increase in the pyridinoline cross-links in collagen, both of which reflect a deterioration in the quality of the bone matrix, Dr.
Differences in levels of urinary markers such as pyridinoline and deoxypyridinoline between the treatment and placebo groups suggested a decrease in the rate of bone resorption.
Serum Vitamin D and Pyridinoline Cross-Linked Carboxyterminal Telopeptide of Type I Collagen in Patients with Ankylosing Spondylitis.
Pyridinoline (PYD) and deoxy-pyridinoline (DPD) are specific cross-links formed within structural collagens between lysine or hydroxylysine residues in the telopeptide region with specific sites within the collagen triple helix, with PYD having 2 forms, hydroxylysyl PYD formed from 3 hydroxylysine residues and lysyl PYD which is derived from 1 lysine and 2 hydroxylysine residues.
The number of pyridinoline cross-links and Hyl residues was expressed per collagenmolecule assuming 300 hydroxyproline residues per triple helix.
Bone densities at the femoral neck and lumbar spine were tested after 24 months, along with serum levels of bone-specific alkaline phosphatase, markers of bone turnover (urinary excretion of pyridinoline and deoxypyridinoline), insulin-like growth factor 1 (IFG-1), and endometrial thickness.
The investigators noted a significant decrease in bone turnover in the alendronate group, as measured by significantly higher urine pyridinoline and urine deoxypyridinoline levels.