pyridinoline


Also found in: Acronyms.

pyr·i·din·o·line

(pir'i-din'ō-lēn),
Hydroxypyridinium; a breakdown product of bone collagen, assayed, as is pyridinium (q.v.), to gauge osteoclastic activity.

py·ri·din·o·line

(pir'i-din'ŏ-lēn)
Hydroxypyridinium; a breakdown product of bone collagen, assayed (as is pyridinium) to measure osteoclastic activity.
References in periodicals archive ?
Comparison of biochemical markers of bone turnover in Paget disease treated with pamidronate and a proposed model for the relationships between measurements of the different forms of pyridinoline cross-links.
total serum alkaline phosphatase; urinary pyridinoline
6 The recommended laboratory test to diagnose ky-phoscoliosis type of Ehlers-Danlos syndrome is the measurement of total urinary hydroxylvsyl pyridinoline ("Pyridinoline") and lysyl pyridinoline ("Deoxypyridinoline") crosslinks after hydrolysis by HPLC, a test with very high degree of sensitivity and specificity.
Pyridinoline (pyr) and deoxypyridinoline (dpyr) are the two nonreducible pyridinium cross-links present in the mature form of collagen.
It will be important to document that the amino-terminal peptide of collagen cross-links (NTX), pyridinoline (PYD), or deoxypyridinoline (DPD) perform as well when subjected to such rigorous study.
We recently reported (8) that the (3-CrossLaps assay for serum Cterminal telopeptide of type I collagen ([beta]-CTX) (9-11) provides values that are no less significant than those for pyridinoline (PYD) and deoxypyridinoline (DPD), 2 commonly used serum bone resorption markers, in assessing bone metabolism in HD patients.
The least significant change amounts for bone alkaline phosphatase (AP), osteocalcin, pyridinoline, deoxypyridinoline, and N-telopeptide are in the range of 15% to 40% (20).
Specific degradation products of the bone matrix, such as DPD and pyridinoline (PYD), closely reflect the rate of bone metabolism.