Among the more commonly implicated are pyrazolone derivatives
, carbamazepine, hydantoin derivatives, cimetidine, lithium salts and gold salts.
3) Other common culprits include the antipyretic metamizole and other pyrazolone derivatives
such as tetracycline, metronidazole, ciprofloxacin, and phenytoin sodium.
Oswal, Microwave assisted synthesis of novel pyrazolone derivatives
attached to a pyrimidine moiety and evaluation of their anti-inflammatory, analgesic and antipyretic activities, Saudi Pharm J.
Pyrazolone derivatives are an important class of heterocyclic compounds that occur in many drugs and synthetic products [1 2].
It was found that pyrazolone derivatives exhibit remarkable analgesic  anti-tubercular  antifungal antibacterial  anti-inflammatory  antioxidant antitumor  insecticidal [11-13] and anticancer activities .
Enaminone 2 was reacted with aniline (3a) 4-chloroaniline (3b) and piperidine (6) to give pyrazolone derivatives 5a
Formation of 12 is believed to be formed via addition of hydrazine to the double bond system of enaminone2 to afford pyrazolone derivative 10a which then loses dimethylamine to give 11a which produces pyrazolopyrazole 12 after losing water (Scheme-2).
General procedure for synthesis of pyrazolone derivative (5a-b)
Keywords: Pyrazolone derivatives, Carboxamides, Urease inhibition, Antibacterial, Antioxidant.
Pyrazolone derivatives have been the interest of research owing to diverse applications such as antioxidant, antimicrobial, cytotoxic, anticancer, antiviral, anticonvulsant, antibacterial , molluscicidal activities [2-7].
We herein report some new pyrazolone derivatives, synthesized to explore their potential urease inhibition properties.
The reaction sequences employed for the synthesis of target pyrazolone derivatives is illustrated in Scheme-1.