Analgesic, anti-inflammatory, antipyretic and toxicological evaluation of some newer 3-methyl pyrazolone
Physicochemical studies of symmetrical tetradentate schiff base complexes of chromium(III), cobalt(II), nickel(II), copper(II), zinc(II), oxovanadium(IV) and dioxouranium(VI) derived from 4-acyl pyrazolone
More recently, other pyrazolone
derivatives have been synthesized and have experimentally demonstrated effective analgesic, anti-inflammatory, antiplatelet, and anticonvulsant activities, among other effects (3).
Metamizole is a pyrazolone
derivate with antipyretic and analgesic properties.
On the other hand, the wide range of biological activities of pyrazolone
as antitumor , anti-inflammatory  and antimicrobial  makes it a basic objective to synthesize biologically active transition metal complexes as it is known that the formation of the complexes enhances the biological efficiency of the ligand .
Among the more commonly implicated are pyrazolone
derivatives, carbamazepine, hydantoin derivatives, cimetidine, lithium salts and gold salts.
PHZ is a pyrazolone
derivative with basic properties used as anti-inflammatory and stabilizer for DD aqueous preparation since the latter is only stable for 2-3 days [2, 3].
(3) Other common culprits include the antipyretic metamizole and other pyrazolone
derivatives such as tetracycline, metronidazole, ciprofloxacin, and phenytoin sodium.
IgE-mediated immediate-type hypersensitivity to the pyrazolone