We therefore performed in vivo and in vitro experiments to assess novelty exploration and recognition memory by a battery of spontaneous behavioural tests and the effect on hippocampal mossy fiber to CA3 pyramidal cells
synapses in wild-type mice after two months of dietary supplementation with H.
The somatic input of CA1 pyramidal cells
has been investigated only in the control and the nonsclerotic epileptic groups (Table 2, ), since pyramidal cells
could be hardly found in the sclerotic CA1 region.
Activation of mGluR5 was tested because of its location on mPFC pyramidal cells
(see the Pain-Related Amygdala-Centered Corticolimbic Interactions section).
Putative pyramidal cells
and interneurons were distinguished by the spike duration , discharge frequency , and autocorrelation function .
1): CA1 contains small pyramidal cells
. Field CA2 is characterized by a narrow, dense band of large pyramidal cells
and field CA3 by a broad, loose band of large pyramidal neurons.
2-4, in the control group I (Cage) and II (Vehicle), pyramidal cells
were typically layered, and were having large, round, transparent, intact nuclei.
In the hippocampus, TrkB-positive cells were mainly concentrated in the granular cell layer of the DG and in the pyramidal cell
layer of the CA1, CA3 and CA4 regions (Figure 3).
The model of the pyramidal cell
physiology consisted of sets of differential equations that describe the active currents and calcium concentration within each compartment and the propagation of voltage potential between compartments.
To correct for processing-induced changes in the volume of the tissue, we calculated a correction factor assuming that the treatments did not alter the total number of pyramidal cells
. In all hippocampi, we examined six or seven disector pairs (pairs of adjacent 2-[micro]m semi-thin sections mounted on slides and stained with toluidine blue).
In rodents, the actions of CA1 pyramidal cells
have striking behavioral correlates.
In females, no significant difference was observed in the total volume estimation of the granular and pyramidal cell
layers of the hippocampus in SD- or HFD-fed groups (Fig.
In addition to pyramidal neurons, the PFC houses parvalbumin-containing GABAergic interneurons, which heavily modulate pyramidal cell