In this study, rats in HFD group showed that histological changes including renal fibrosis and tubular necrosis, degenerated epithelial cells, necrotic debris in tubular lumen, pyknotic
nuclei and inflammation were clearly improved, as well as the reno-protective effect of ginger extract (Nwaopara et al., 2008).The ultrastructural perceptions of the renal sections of HFD group revealed an increase in the glomerular endothelial cells and collagen fibrotic glomerulopathy in the mesangium and the mesangial cells.
(B) Epileptic (PTZ-treated) rat shows many neurons with dark pyknotic
Neutrophil Changes Erythrocyte Changes Cytoplasmic vacuoles Crenated (burr cells, echinocytes) Loss of granulations Spherocytes Elongated nuclei Elongated (elliptocytes) (loss of segmentation) Undefined chromatin Schistocytes (fragments) (appear liquefied) Pyknotic
nuclei (necrobiotic) Hypochromic Cytoplasm rupture Smudge (basket) cells
The most characteristic progestin-associated change is the appearance of myocytes with pyknotic
nuclei and abundant deeply eosinophilic cytoplasm adjacent to the necrotic areas.
Some of their nuclei appeared pyknotic
and karyorrhectic compared with the control group (Figure 2c).
Atretic follicles had oocyte with a pyknotic
nucleus of oocyte and granulosa cells and shrunken ooplasm.
Necrotic cells presented chromatin forms with irregularly shaped aggregates, a pyknotic
nucleus (shrunken and darkly stained), and cell membrane disruption, with cellular debris spilled into the extracellular milieu.
The neoplasm was composed of spindle-cells with pyknotic
nuclei and rare mitotic figures and a modest degree of nuclear pleomorphism.
On the contrary, heart sections of diabetic rats showed myocardial degeneration and pyknotic
nuclei (Figure 3(c)).
Figure 7(f) represents the mean of percent of pyknotic
neurons in each group and highlights that PTZ-kindled mice show greater percent of pyknotic
neurons in comparison to the percent registered in saline group.
Some cells were juxtaposed to suggest molding, with many cells containing pyknotic
nuclei, indicative of a rapidly growing tumor (Figure 2(b)).
The nucleus is decreased in size with folding in its surface and condensed chromatin, which gives a pyknotic