Histopathological findings in liver mostly showed vascular degeneration associated with nuclear pyknosis
; also it is found in liver marked depletion and congestion of the portal vein accompanied with nuclear pyknosis
It is known that ooplasmic vacuolation and GC pyknosis
are observed simultaneously with early antrum formation in atretic follicles (21, 33).
(c) Sinusoidal dilatation and pyknosis
, H&E stain.
sinensis-administered group showing normal histological structures of the medullary neurons, (g-i) the nicotine-exposed group revealing pyknosis
and chromatolysis (arrow) of the medullary neurons (MN), and (j-l) the C.
Panels A-G show that the morphology of Saos-2 cells cultured in different extracts for 72 h was normal and healthy, similar to that of the negative control, but the 5% DMSO positive control revealed many apoptotic cells, manifested as nuclear pyknosis
All the follicles were classified as either healthy or atretic, respectively, according to the absence or presence of signs of oocyte and/or granular degeneration such as pyknosis
of the nucleus, infolding of the cell wall in oocyte, ingression of granulosa cells within the antral cavity, pulling away of granulosa cells from the basement membrane, infolding or thickening of base membrane and uneven layers of granulosa cells (27).
In the present study, spermatogenesis was disrupted in ischemia only group and more affected in I/R group in the form of pyknosis
and degeneration of the spermatogonia together with their separation from the basement membrane which were similar to Bergh et al.
In line with our in vitro results, the subcutaneous xenogeneic or allogeneic co-administration of different intestinal adenocarcinoma cell line in murine model with sesquiterpene compound, Ferutinin, resulted in slower tumor growth rate with concurrent nuclear pyknosis
and apoptosis (Arghiani et al.
In this condition, the superficial portion of the squamous epithelium becomes necrotic, giving a two-tone appearance to the mucosa, with pyknosis
resembling parakeratosis and necrosis of the superficial layers (Figure 3, A and B).
Hypertrophy and pyknosis
are signs of cellular degeneration (Garman, 2011), and may arise when a chemical agent traumatizes the brain.
(10, 11) These include: islands of well differentiated squamous cells present at all levels of the epithelium; disorganized cellular polarity; cellular pleomorphism; presence of nucleoli in some cells; frequent pyknosis
; and individual cell keratinisation.
Malathion administration also reduced epididymal weight , whereas increased weight of epididymis and cellular necrosis, nuclear pyknosis
, and a deleterious effect on the structural integrity following methyl parathion exposure were observed [61, 64].