A clinical trial in palmoplantar pustulosis
(PPP) patients was successfully conducted by Genmab and the drug has potential application in autoimmune diseases, besides oncology.
Synovitis, acne, pustulosis
, hyperostosis, and osteitis (SAPHO) syndrome is a rare group of sterile, inflammatory osteoarticular disorders classically associated with skin manifestations.
Acute generalized exanthematous pustulosis
, a clue to neutrophil-mediated inflammatory processes orchestrared by T cells.
HS also has been reported as a comorbid condition in patients with several rare syndromes, including SAPHO (synovitis, acne, pustulosis
, hyperostosis, and osteitis) and PAPA (pyogenic arthritis, pyoderma gangrenosum, and acne) syndromes.
of the folds (APF) is a chronic, relapsing sterile pustular eruption involving the main cutaneous flexures, scalp, and periorificial regions occurring mostly in young females.
Summarizing the symposium and covering both basic and clinical research on the topic, the papers address immunology and mucosal defense systems; bacteriology and virology; mucosal vaccines for upper airway infections; mucosa-associated and nasopharynx-associated lymphoid tissue; clinical manifests and pathogenesis of tonsil-related diseases such as IgA nephropathy, palmoplantal pustulosis
, reactive arthritis diseases, and others; the association of tonsils with otitis media; allergic diseases in the upper airways; obstructive sleep apnea; and medical and surgical treatments for tonsil diseases.
Acute generalised exanthematous pustulosis
(AGEP) is characterised by 1 - 3 mm sterile pustules on a background of generalised oedematous erythema, 12 - 24 hours after ingesting the offending drug (Fig.
Based on the clinical and radiographic presentation, the SAPHO (synovitis, acne, pustulosis
, hyperostosis, and osteitis) syndrome associated with severe HS was diagnosed.
T-cell involvement in drug induced acute generalized exanthematous pustulosis
Hyperkeratotic eczema of the palms and palmoplantar pustulosis
may be difficult to differentiate from psoriasis.
18) As well, bisphosphonate therapy may be beneficial in conditions that mimic osteonecrosis such as SAPHO syndrome (synovitis, acne, pustulosis
, hyperostosis and osteitis) of the mandible, in which the histologic appearance may resemble that of osteonecrosis.
Clinical signs included pustulosis
or furunculosis (3 patients) and abscesses (7 patients).