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Zambusch,Leo von, 20th century German physician.
psoriasischronic skin condition, characterized by circumscribed, discrete and confluent, crimson red, silver-scaled, plaque-like inflammatory skin lesions, affecting 2% of population; exacerbated by stress, drugs (e.g. non-steroidal anti-inflammatory drugs, beta-blockers, angiotensin-converting enzyme inhibitors, lithium, alcohol, hydroxyquinoline), streptococcal infections, and trauma (due to Koebner phenomenon); plaques show local epidermal thickening, hypervascularity, abnormality of T-lymphocyte function, proliferation and altered differentiation of keratinocytes and parakeratosis; lesions characteristically affect extensor surfaces, scalp and trunk; nails become dystrophic, showing onycholysis, subungual hyperkeratosis and thimble pitting; small joints of hands and feet may develop psoriatic arthropathy; treated by systemic cytotoxic drugs (e.g. methotrexate, ciclosporin, azathioprine, efalizumab, hydroxycarbamide) and acitretin or topical applications, e.g. emollients, for mild presentations; coal tar ointments and balms; vitamin D analogue ointment (e.g. calcipotriol); dithranol, phototherapy (using ultraviolet B), photochemotherapy (using psoralens and long-wave ultraviolet light [PUVA])
guttate psoriasis widely scattered, multiple psoriatic lesions; distribution resembles raindrops on a dry pavement; characteristically develops after streptococcal throat infection
pustular psoriasis formation of sterile 'pustules' often of plantar skin; associated with generalized psoriasis