Clinical characteristics Classic HFMD Age of patients Children < 7 years Peak incidence Summer and spring Skin lesions Maculopapular lesions with vesicles Skin lesion distribution Oral cavity, palms and soles (palmar site) Complications Rare Prodromal symptoms Rare; if present, mild Clinical characteristics CVA6-related HFMD Age of patients Predominantly adults Peak incidence Winter Skin lesions Purpuric
lesions Skin lesion distribution More widespread (perioral area, dorsum of hands and feet, trunk, extremities) Complications More common (meningitis, encephalitis) Prodromal symptoms Often higher fever (> 38.5 [degrees]C) HFMD = hand, foot, and mouth disease; CVA16 = coxsackievirus A16.
Common primary onset symptoms of pSS patients comprised of xerophthalmia (dry eyes), xerostomia (dry mouth), joint pain, parotid enlargement, rampant caries, purpuric
eruptions, a reduction in circulating blood platelets, and hypokalemic periodic paralysis.
Conclusion: In this study, we found a significant correlation between MPV and pigmented purpuric
Overnight, her extremity swelling worsened and she developed new purpuric
lesions, though remained well appearing.
However, atypical rashes have also been reported, such as persistent purpuric
papules and plaques, urticaria, dermographism or linear pigmentation, generalized erythema, dermatomyositis-like plaques, vesiculopustules on hands and feet, prurigo pigmentosa-like plaques, and lichen amyloidosis-like hyperpigmented plaques [2-7].
The patient's purpuric
rash improved significantly and rapidly with intravenous solumedrol, but his scrotal pain and edema persisted and patient developed painful penile ulcer.
(b) Corresponding hematoxylin and eosin-stained histopathology at 20x magnification of a punch biopsy of one of the lesions on his leg, showing mild perivascular inflammation with focally extravasated erythrocytes consistent with a resolving purpuric
rash was seen in 3 patients only (Table-I).
Purpura is sometimes a sign of a potentially serious disorder so you should always consult your doctor as a matter of urgency if you note a purpuric
The clinical spectrum of the disease is quite variable, from asymptomatic to fulminant forms, but almost only diagnosed after the typical purpuric
rash appearance in a patient with a history of tick bites.
(12) Patients typically present with a tender, purpuric
rash in a retiform or stellate pattern with or without central necrosis involving the extremities, trunk, nasal tip, digits, cheeks, and/or ears (Figure 1).