The pathways related to the glycolysis, purine metabolism
, protein degradation, pentose pathway, and nicotinamide metabolism in the KEGG database were extracted as the molecular biological events associated with the significantly changed compounds (p< 0.05) during the postmortem aging of the LT muscle.
Wang et al., "A canonical correlation analysis of AIDS restriction genes and metabolic pathways identifies purine metabolism
as a key cooperator," Computational and Mathematical Methods in Medicine, vol.
(1) Glycerophospholipid metabolism; (2) amino acid metabolism; (3) energy metabolism; (4) purine metabolism
Uric Acid (UA) is the final product of the activity of xanthine oxidase (XO) in the purine metabolism
. The enzyme, XO linked to oxidative stress, endothelial dysfunction and heart failure in humans.
The metabolic pathway genes that highly correlated with the variable P4 are enriched in purine metabolism
. These genes include deoxyguanosine kinase (1716), polymerase (RNA) III (DNA directed) polypeptide K (51728), polymerase (RNA) III (DNA directed) polypeptide B (55703), pyruvate kinase (5313), adenylate cyclase 10 (55811), phosphodiesterase 6D (5147), polymerase (DNA directed), delta 2 (5425), polymerase (RNA) II (DNA directed) polypeptide C (5432), and phosphodiesterase 5A (8654).
Gout is caused by disordered purine metabolism
resulting in hyperuricemia.
Muller's major research interests are related to purine metabolism
and clinical and applied biochemistry.
, including the final steps in uric acid generation catalyzed by xanthine oxidase, have been exceedingly well-characterized.
Repligen Corporation (Needham, MA; 781-449-9560) announced that it has licensed two patent applications from the University of California (San Diego, CA) covering novel methods for the treatment of mitochondrial disease and for the treatment of autism in patients with abnormal purine metabolism
Uric acid is the product of purine metabolism
and has physiological interactions with thyroid hormone levels.
Uric acid is produced by the enzymatic activity of xanthine oxidase and is the final product of purine metabolism
.4 Xanthine oxidase produces oxidants in this process that may have a role in cardiovascular disease and kidney dysfunction.5
Schluteret al., "Deregulation of purine metabolism
in Alzheimer's disease," Neurobiology of Aging, vol.