pure red cell aplasia


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pure red cell a·pla·si·a

a transitory arrest of red blood cell production that may occur in the course of a hemolytic anemia, often preceded by infection, or as a complication of certain drugs; if the arrest persists, severe anemia may result.
See also: congenital hypoplastic anemia.

pure red cell aplasia

Hematology A type of anemia caused by selective depletion of erythroid cells
Pure red cell aplasia types
Acute Aplastic crisis A condition often preceded by viral gastroenteritis, pneumonitis, primary atypical pneumonia, mumps, viral hepatitis, pregnancy and drug toxicity Clinical Malaise, pallor and other symptoms of a chronic, compensated hemolyzing process Treatment The only effective modality is discontinuance of inculpated drug, if identified
Chronic Either
1.Congenital Diamond-Blackfan disease A condition due to a ↓ in erythrocyte stem cells with ↓ colony-forming units and burst-forming units and a poor response to erythropoietin Treatment Transfusions, corticosteroids or.
2. Acquired 30-50% of chronic acquired PRCA is associated with thymoma, as well as rheumatoid arthritis, lupus erythematosus, chronic active hepatitis, hemolytic anemia and CLL  
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pure red cell aplasia

A severe failure of production of red blood cells by the bone marrow with normal production of other blood cells. The result is a temporary or persistent severe anaemia. The condition may be caused by some virus infections, some drugs, cancers, rheumatoid arthritis and systemic lupus erythematosus.
References in periodicals archive ?
Adamson, "Pure red cell aplasia: lymphocyte inhibition of erythropoiesis," British Journal of Haematology, vol.
Zidovudine-induced reversible pure red cell aplasia. Indian Journal Of Pharmacology 2010;42:189-191.
Pure red cell aplasia in systemic lupus erythematosus.
Pure red cell aplasia was suspected in this case because of the presence of marked anaemia in a background of several units of blood transfusion along with presence of thymoma.
(2.) Dessypris EN: The biology of pure red cell aplasia. Semin Hematol 1991; 28: 275-284
There is no cross reaction between peginesatide and anti-erythropoietin antibodies, or between anti-peginesatide antibodies and erythropoietin; thus, pure red cell aplasia is unlikely to occur (Woodburn et al., 2007).
Zidovudine-induced pure red cell aplasia presenting after 4 years of therapy.
Moreover, reports of antibody-mediated pure red cell aplasia secondary to the administration of a recombinant erythropoietin had already spurred interest in neutralizing antibodies (NAb) and focused attention on immunogenicity testing (7).
Pure red cell aplasia is a rare but serious side effect associated with all three products.
Pure red cell aplasia due to parvovirus B19 in a patient treated with rituximab.
A rare complication, pure red cell aplasia, has been reported due to the development of antibodies to Eprex, an epoetin alpha product available outside the U.S.
INTRODUCTION: Pure red cell aplasia (PRCA) is an uncommon disorder in which maturation arrest occurs in the formation of erythrocytes.