A drug-eluting core is inserted into Mati's proprietary punctal plug
, which allows medication to be continuously released into the tear film of the eye over a period of time.
IOP was lowered significantly with punctal plugs
(MD, 1.5 mm Hg).
The patents cover 17 patent families, including important elements of the Evolute punctal plug
delivery system for treatment of ocular indications.
Long-term follow-up punctal and proksimal canalicular stenoses after silicone punctal plug
teratment in dry eye patients.
The Phase II trial featured simultaneous placement of punctal plugs
in both the upper and lower puncta for delivery of a daily drug load with a goal of enabling comparable clinical outcomes to that of daily administered Xalatan eye drops.
In more severe cases or when dryness becomes chronic, other treatment modalities include cyclosporine A 0.05% (Restasis) , autologous serum eye drops , and punctal plugs
Treatments can include artificial tears, punctal plugs
, special sunglasses and other prescriptions to alleviate the problem.
Offering recommendations to improve eye health and appearance without resorting to surgery, The Dry Eye Remedy includes advice for improving one's home environment, proper nutrition, how to set up a "home eye spa", which over-the-counter remedies are harmful, the pros and cons of medical treatments such as hormone therapy or punctal plugs
, and a guide to deciding upon the dry eye therapy that works best for the reader.
Collagen punctal plugs
eventually dissolve, and often are used to see whether permanent plugs will help the eye retain tears and can be tolerated by the patient.
provide another option for women with dry eye.
Current treatments for dry eye syndrome are limited to eye drops, synthetic tears, punctal plugs
, dietary changes and a prescription medication that treats eye inflammation.
"This new work confirms our earlier work, and explains why patients improve with hypotonic tears, punctal plugs
, hot compresses and moist chambers--all treatments that help lower elevated tear film osmolarity in dry eye, reduce patient symptoms, decrease ocular surface disease, and now evidently reduce the secondary ocular surface inflammation," he says.