Colten, "Deficiency of pulmonary surfactant
protein B in congenital alveolar proteinosis," New England Journal of Medicine, vol.
Weaver, "Pulmonary surfactant
pathophysiology: current models and open questions," Physiology, vol.
Evidence for a protective role of pulmonary surfactant
protein D (SP-D) against influenza A viruses.
It is known that pneumocyte type II (P2) is the main source of phospholipid and protein components of pulmonary surfactant
Similarly, the instillation of pulmonary surfactant
into the lungs of ARDS patients has had no significant clinical benefit.
protein D in sera and bronchoalveolar lavage fluids.
Antigen-induced airway inflammation in atopic subjects generates dysfunction of pulmonary surfactant
. Am J Respir Crit Care Med 1999;160:336-41.
Discovery Labs' novel proprietary KL4 surfactant technology produces a synthetic, peptide-containing surfactant that is structurally similar to pulmonary surfactant
and is being developed in liquid, lyophilized and aerosolized formulations.
Restrictive ventilatory impairment in children could be caused by decreased pulmonary surfactant
, reduced lung growth for age, chronic obstruction, or fibroric changes.
The mature levels of pulmonary surfactant
are usually present after 35 weeks of gestation (15).
: functions and molecular composition.
Changes in pulmonary surfactant
function and composition in bleomycin-induced pneumonitis and fibrosis.