pulmonary surfactant


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pulmonary surfactant

A lipoprotein secreted by type II alveolar cells that decreases the surface tension of the fluid lining the alveoli, permitting expansion. Synthetic lung surfactant is available for treating patients with respiratory distress syndrome. In obstetrics, fetal production of surfactant can be stimulated by administration of a glucocorticoid 24 to 48 hr before an inevitable preterm birth.
Synonym: lung surfactant See: betamethasone; lecithin-sphingomyelin ratio
See also: surfactant
References in periodicals archive ?
Colten, "Deficiency of pulmonary surfactant protein B in congenital alveolar proteinosis," New England Journal of Medicine, vol.
Weaver, "Pulmonary surfactant pathophysiology: current models and open questions," Physiology, vol.
It is known that pneumocyte type II (P2) is the main source of phospholipid and protein components of pulmonary surfactant (Enhorning, 2008).
Similarly, the instillation of pulmonary surfactant into the lungs of ARDS patients has had no significant clinical benefit.
Antigen-induced airway inflammation in atopic subjects generates dysfunction of pulmonary surfactant. Am J Respir Crit Care Med 1999;160:336-41.
Discovery Labs' novel proprietary KL4 surfactant technology produces a synthetic, peptide-containing surfactant that is structurally similar to pulmonary surfactant and is being developed in liquid, lyophilized and aerosolized formulations.
Restrictive ventilatory impairment in children could be caused by decreased pulmonary surfactant, reduced lung growth for age, chronic obstruction, or fibroric changes.
The mature levels of pulmonary surfactant are usually present after 35 weeks of gestation (15).
Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis.