lung interstitium

(redirected from pulmonary interstitium)

lung interstitium

A general term for the connective tissue-rich supportive framework of the lung, which is divided into alveolar interstitium, axial interstitium, and peripheral interstitium.
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[1,2] In most cases the pathology of ILD lies in the pulmonary interstitium which consist of connective tissue space between the alveolar epithelial cells and the adjacent capillary endothelial cells.
(8) reported that infiltration of ATL cells into the pulmonary interstitium results in interlobular septal thickening, and ATL cells that infiltrate the walls of respiratory bronchioles extend into the adjacent peribronchiolar interstitium, which leads to multiple centrilobular nodules on CT.
A large number of lymphocytes also infiltrated the pulmonary interstitium. The level of pathologic changes in siRNA control group was higher that of the negative control group.
(8) Although much of the literature suggests that the condition is self-limiting, life-threatening complications such as tension pneumomediastinum, single or bilateral pneumothorax or tension pneumothorax, and increased pressure in the pulmonary interstitium leading to dyspnea have been described.
* ILD refers to a group of disorders that primarily affects the pulmonary interstitium, rather than the alveolar spaces or pleura.
While the pulmonary interstitium is most commonly affected [2], extrapulmonary involvement can occur in almost any other organ system [3] including the skin, eyes, and abdominal organs [2].
NEDD9 immunoreactivity was also observed in the cytoplasm and nuclei of the bronchial and pulmonary epithelial cells, and in the mesenchymal cells of the pulmonary interstitium. NEDD9 immunoreactive cells were rarely found in the non-emphysematous areas of human lung (Figure 7).
We assessed tissue specimens for other concurrent manifestations of autoimmunity outside the pulmonary interstitium but within the thoracic compartment, termed multicompartment involvement (Table 1).
There were multiple nodular neoformations with hemorrhagic areas showing a circumferential growth that affected blood vessels and bronchioles, which extended to adjacent areas and to the subpleural pulmonary interstitium. Vimentin stain, CD34, CD31, and VIII factor all resulted to be positive.
The lung contained well-demarcated regions of severe hemorrhage, and the pulmonary interstitium was expanded by edema and an inflammatory infiltrate of lymphocytes, histiocytes, and heterophils admixed with karyorrhetic debris and eosinophilic fibrillar material (fibrin).
MRI is not widely used in lung imaging due to limited spatial rezolution,1,2 high contrast difference between pulmonary interstitium and airways, and pulmonary and cardiac motion artefacts.3 CT has the advantage of imaging both alveolar and pulmonary interstitium without the use of intravenous (IV) contrast material.4,5 On the other hand, CT has some disadvantages such us contrast medium-causes nephrotoxicity and radiation dose, especially in the followup lung lesions.5,6 Since radiation has the risk of lung cancer formation itself, alternative imaging modalities are researched for the followup of lung lesions.7
(1), (3) Another uncommon thoracic complication is involvement of the pulmonary interstitium that can cause acute and rapidly fatal respiratory failure, (5), (6) and the formation of pleural masses that usually are asymptomatic but, rarely, develop haemothorax.

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