The identification of fat attenuation within a smooth or lobulated SPN on thin-section CT is diagnostic of a pulmonary hamartoma (Figure 6).
These are central, laminated, or diffuse calcification as seen within granulomas, and popcorn calcification seen in pulmonary hamartomas (Figure 3).
Probable malignant transformation of a pulmonary hamartoma.
Fine needle aspiration biopsy of pulmonary hamartomas.
This factor is known to play a significant role in the frequent misdiagnoses of pulmonary hamartoma
(18) and in rare cases of pulmonary sequestration (15); in both lesions, the culprit is the abundant benign cohesive epithelium often misinterpreted as well-differentiated adenocarcinoma.
Benign lung tumors in the differential diagnosis include clear cell tumor, pulmonary hamartoma
, and hemangioma.
Hematoxylin-eosin-stained slides of all 38 cases of pulmonary hamartoma were reviewed for the presence of villus papillary projections or placenta-like structures.
Thirty-eight cases of pulmonary hamartoma resected by wedge resection or lobectomy were identified from departmental records.
Pulmonary hamartomas are common benign tumors often located within the peripheral lung parenchyma.
Pulmonary hamartomas are common benign lesions, which typically arise within the peripheral lung parenchyma and are commonly discovered on CT examination as incidental findings.
While a hamartoma is defined as disordered growth of tissues normally present within the organ, pulmonary hamartomas are clonal proliferations and therefore neoplastic.
Pulmonary hamartomas contain at least 2 benign/mature mesenchymal tissues, one of which is often cartilage (Figure 3, B).