Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods
. J Clin Res Pediatr Endocrinol.
Consistent with the timing of the pubertal period
, peak concentrations occurred at the ages of 13-14 years in girls and at 15-16 years in boys, with slightly higher values in girls than in boys.
Earlier findings have also reported that plasma levels of GH, which are low at the pre-pubertal stage, rise with the onset of puberty in humans, peak during mid to late puberty and decline progressively during post pubertal period
to reach very low concentrations at adulthood (Martha et al., 1989, 1992; Rose et al., 1991).
Kanbur et al (2005) found sexual maturation stages in pubertal period
would not effective in determining the flexibility at their study.
Testosterone, growth hormone and insulin-like growth factor-1 increase during the pubertal period
(Bailey et al., 1996) enhancing bone growth and turnover through osteoblastic stimulation (Hock et al., 1988).
On the other hand, always with reference to muscle fibres, it is important to signal that their differentiation (in fast fibres and resistant fibres) is consolidated only at the end of the pubertal period
, and in this phase a predominance of fast fibres clearly guarantees a greater degree of strength.
Data gathered in this way do not provide information about the unique response of adolescents to toxicants because the exposures occur throughout development and are not limited to the pubertal period. One study was located using several estrogenic agents and evaluating vaginal opening (142), but most studies of this type begin exposure at or before weaning.
Mice were allowed ad libitum access to a liquid diet containing 5% ethanol beginning at weaning through the pubertal period (49 days of age).