Researchers determined when they showed initial signs of thelarche (breast development), pubarche
(pubic hair growth) and menarche (start of menstrual periods).
The prevalence and risk factors of premature thelarche and pubarche
in 4 to 8 year old girls.
Patients may have spontaneous breast and pubic hair development, oligomenorrhea or secondary amenorrhea while complete forms have absent pubarche
Pubertal onset was defined as reaching Stage 2 for breast development (thelarche), pubic hair development (pubarche
), or genital development (gonadarche).
Reference values for serum dehydroepiandrosterone-sulphate in healthy children and adolescents with emphasis on the age of adrenarche and pubarche
. Clin Endocrinol (Oxf) 2015;82:712-8.
Prevalence of nonclassic congenital adrenal hyperplasia in Turkish children presenting with premature pubarche
, hirsutism, or oligomenorrhoea.
NC forms of CAH are more common than classic forms, occurring in 1-3% of the general population, and are often misdiagnosed as precocious pubarche
or polycystic ovarian disease in young women.
, and menarche attainment in children with normal and elevated body mass index.
Children present with precocious pubarche
, accelerated growth velocity, and advanced skeletal maturation .
Clinical features of 11-[beta]-hydroxylase deficiency in childhood might be premature pubarche
and accelerated bone age, all of which occurred in our patient.
Battagliaetal (16) reported an increased incidence of polycystic ovaries detected by ultrasound in daughters of patients with PCOS, even of pre pubertal age, with no increase in circulating androgens or LH, but with increased ovarian and uterine volume and a higher incidence of early pubarche
in initial stages.
Drum, "Thelarche, pubarche
, and menarche attainment in children with normal and elevated body mass index," Pediatrics, vol.