NC forms of CAH are more common than classic forms, occurring in 1-3% of the general population, and are often misdiagnosed as precocious pubarche
or polycystic ovarian disease in young women.
2014), but was inversely associated with odds of having reached adrenarche or pubarche
in boys (n =107) (Ferguson et al.
Children present with precocious pubarche
, accelerated growth velocity, and advanced skeletal maturation .
Clinical features of 11-[beta]-hydroxylase deficiency in childhood might be premature pubarche
and accelerated bone age, all of which occurred in our patient.
Battagliaetal (16) reported an increased incidence of polycystic ovaries detected by ultrasound in daughters of patients with PCOS, even of pre pubertal age, with no increase in circulating androgens or LH, but with increased ovarian and uterine volume and a higher incidence of early pubarche
in initial stages.
17 Another American study18 showed that 6-9 year-old white girls who had only pubic hair had higher BMI and z-scores than pre-pubertal girls without pubarche
, unlike the African-American girls.
The disorder should be considered and a thorough work-up performed in prepubertal girls who have risk factors suggestive of PCOS, with particular attention given to hyperinsulinemia and early pubarche
and thelarche, recommended researchers Dr.
The disorder should be considered and a thorough workup performed in prepubertal girls who have risk factors suggestive of PCOS, with particular attention given to hyperinsulinemia and early pubarche
and thelarche, said Dr.
Major Finding: Preadolescent girls (aged 9-12) can develop PCOS, and physicians should suspect the disorder in girls with early-onset pubarche
or thelarche as well as those with traditional risk factors including hyperinsulinemia and a family history of PCOS.
Data from the last few decades show a dramatic decline in the onset age for both breast budding and pubarche
, and rates are continuing to decline.
, ovarian hyperandrogenism, hyperinsulinism and the polycystic ovary syndrome: from a complex constellation to a simple sequence of prenatal onset.
However, data from the last few decades have shown a dramatic decline in the onset age for both breast budding and pubarche
and these rates are continuing to decline significantly (unlike menarche onset which has appeared to plateau).