Immunohistochemical studies of HS surgical specimens from 18 patients demonstrated high levels of antimicrobial peptides (AMPs), including
psoriasin and human beta-defensin, in the epidermis.
S100A7 (
psoriasin), S100A8 (calgranulin A), S100A9 (calgranulin B), and S100A12 (calgranulin C) are markedly increased in psoriasis lesions [2, 75].
In similar models (postmenopausal women treated with estrogens), a diminished risk of bacterial infections has been observed due to the increase of mRNA coding for the AMPs HBD-1 and HBD-3, as well as
psoriasin and cAMP [3, 6, 8].
Novel S100A7 (
psoriasin)/ S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function.
Enerback, "Cluster analysis of S100 gene expression and genes correlating to
psoriasin (S100A7) expression at different stages of breast cancer development," International Journal of Oncology, vol.
Glaser, "Differential expression and in vivo secretion of the antimicrobial peptides
psoriasin (S100A7), RNase 7, human beta-defensin-2 and -3 in healthy human skin," Experimental Dermatology, vol.
[5] Vitamin D analogs suppress Th17-induced proinflammatory functions of
psoriasin and koebnerisin, and thus, interfere with the inflammatory feedback loop in psoriatic skin.
Psoriasin (S100A7) associates with integrin [beta]6 subunit and is required for [alpha]v[beta]6-dependent carcinoma cell invasion.
According to Reisner, syndicated data indicate that
Psoriasin Ointment remains the No.
Another protein,
psoriasin, is found in the urine of bladder cancer patients and can be used as an early diagnostic marker for the disease.
Psoriasin (S100A7): a putative urinary marker for the follow up of patients with bladder squamous cell carcinomas.
In combination with another antimicrobial peptide,
psoriasin, LL-37 was even more effective against P.
