psoriasin

psoriasin

(sōr-ī-ah'sin),
A compound found in normal skin, increased in psoriasis, which inhibits growth of E. coli, but not of other common skin bacteria.

S100A7

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The function of the  S100A7-encoded protein is unknown.
 
Molecular pathology
S100A7 is overexpressed in the skin lesions of psoriasis, but is not a candidate gene for familial psoriasis.
References in periodicals archive ?
Bladder squamous cell carcinomas express psoriasin and externalize it to the urine," Journal of Urology, vol.
Psoriasin (S100A7) associates with integrin [beta]6 subunit and is required for [alpha]v[beta]6-dependent carcinoma cell invasion.
According to Reisner, syndicated data indicate that Psoriasin Ointment remains the No.
Another protein, psoriasin, is found in the urine of bladder cancer patients and can be used as an early diagnostic marker for the disease.
Psoriasin (S100A7): a putative urinary marker for the follow up of patients with bladder squamous cell carcinomas.
In combination with another antimicrobial peptide, psoriasin, LL-37 was even more effective against P.
Additional studies currently are exploring whether the levels of this protein in the CSF are regulated as a function of the progression of dementia, and initial results suggest that psoriasin levels do indeed increase with advancing dementia.
VIENNA -- Healthy skin secretes an antimicrobial protein called psoriasin that is a potent Escherichia coli-killing compound, Regine Glaser, M.
Glaser used an antipsoriasin monoclonal antibody to show that high concentrations of psoriasin were produced selectively by keratinocytes located in the upper, more differentiated epidermal layers of the nose, the anogenital area, the armpits, and the sebaceous glands--all sites with high bacterial colonization rates.
Through these studies they discovered a potential tumor marker, psoriasin, excreted in the urine of patients with squamous cell bladder carcinoma (8).
offers the Psoriasin line of medically recognized formulas to provide complete and effective treatment for the symptoms of psoriasis and seborrheic dermatitis.
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