psoriasin

(sōr-ī-ah'sin),

A compound found in normal skin, increased in psoriasis, which inhibits growth of E. coli, but not of other common skin bacteria.

S100A7

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The function of the S100A7-encoded protein is unknown.

Molecular pathology
S100A7 is overexpressed in the skin lesions of psoriasis, but is not a candidate gene for familial psoriasis.

References in periodicals archive ?

Bladder squamous cell carcinomas express psoriasin and externalize it to the urine," Journal of Urology, vol.

From normal skin to squamous cell carcinoma: a quest for novel biomarkers

Psoriasin (S100A7) associates with integrin [beta]6 subunit and is required for [alpha]v[beta]6-dependent carcinoma cell invasion.

Mechanisms of Invasion in Head and Neck Cancer

According to Reisner, syndicated data indicate that Psoriasin Ointment remains the No.

Alva-Amco adding to specialty O-T-C portfolio

Another protein, psoriasin, is found in the urine of bladder cancer patients and can be used as an early diagnostic marker for the disease.

Proteomics: an evolving technology in laboratory medicine

Psoriasin (S100A7): a putative urinary marker for the follow up of patients with bladder squamous cell carcinomas.

Intermittent self-catheterization and the risk of squamous cell cancer of the bladder: An emerging clinical entity?

In combination with another antimicrobial peptide, psoriasin, LL-37 was even more effective against P.

Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill Propionibacterium acnes

Additional studies currently are exploring whether the levels of this protein in the CSF are regulated as a function of the progression of dementia, and initial results suggest that psoriasin levels do indeed increase with advancing dementia.

Systems biology in the study of neurological disorders: focus on alzheimer's disease

VIENNA -- Healthy skin secretes an antimicrobial protein called psoriasin that is a potent Escherichia coli-killing compound, Regine Glaser, M.

Endogenous psoriasin protects skin from E. coli infection

Glaser used an antipsoriasin monoclonal antibody to show that high concentrations of psoriasin were produced selectively by keratinocytes located in the upper, more differentiated epidermal layers of the nose, the anogenital area, the armpits, and the sebaceous glands--all sites with high bacterial colonization rates.

Endogenous protein protects skin from E. coli

Through these studies they discovered a potential tumor marker, psoriasin, excreted in the urine of patients with squamous cell bladder carcinoma (8).

Identification by proteomic analysis of calreticulin as a marker for bladder cancer and evaluation of the diagnostic accuracy of its detection in urine

offers the Psoriasin line of medically recognized formulas to provide complete and effective treatment for the symptoms of psoriasis and seborrheic dermatitis.

The first line of defense for psoriasis

WALGREENS NICHE PICKS * PRODUCT MANUFACTURER ActivOn products Miralus Biotene Mouthwash Laclede Biotene Toothpaste Laclede Breathe Right GlaxoSmithKline Cold-Eeze Quigley Hyland's Hyland's Milani Cosmetics The New Milani Group Psoriasin Alva-Amco Pharmacal Similasan Ear Care Similasan Similasan Eye Care Similasan Sinucleanse Med-Systems Yes To Carrots Yes To * This is the first of eight charts in this section that reflect the responses of a number of national and regional drug chains when asked to provide a list of important niche brands.