psoriasin

psoriasin

(sōr-ī-ah'sin),
A compound found in normal skin, increased in psoriasis, which inhibits growth of E. coli, but not of other common skin bacteria.

S100A7

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The function of the  S100A7-encoded protein is unknown.
 
Molecular pathology
S100A7 is overexpressed in the skin lesions of psoriasis, but is not a candidate gene for familial psoriasis.
References in periodicals archive ?
Immunohistochemical studies of HS surgical specimens from 18 patients demonstrated high levels of antimicrobial peptides (AMPs), including psoriasin and human beta-defensin, in the epidermis.
S100A7 (psoriasin), S100A8 (calgranulin A), S100A9 (calgranulin B), and S100A12 (calgranulin C) are markedly increased in psoriasis lesions [2, 75].
In similar models (postmenopausal women treated with estrogens), a diminished risk of bacterial infections has been observed due to the increase of mRNA coding for the AMPs HBD-1 and HBD-3, as well as psoriasin and cAMP [3, 6, 8].
Novel S100A7 (psoriasin)/ S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function.
Enerback, "Cluster analysis of S100 gene expression and genes correlating to psoriasin (S100A7) expression at different stages of breast cancer development," International Journal of Oncology, vol.
Glaser, "Differential expression and in vivo secretion of the antimicrobial peptides psoriasin (S100A7), RNase 7, human beta-defensin-2 and -3 in healthy human skin," Experimental Dermatology, vol.
[5] Vitamin D analogs suppress Th17-induced proinflammatory functions of psoriasin and koebnerisin, and thus, interfere with the inflammatory feedback loop in psoriatic skin.
Psoriasin (S100A7) associates with integrin [beta]6 subunit and is required for [alpha]v[beta]6-dependent carcinoma cell invasion.
According to Reisner, syndicated data indicate that Psoriasin Ointment remains the No.
Another protein, psoriasin, is found in the urine of bladder cancer patients and can be used as an early diagnostic marker for the disease.
Psoriasin (S100A7): a putative urinary marker for the follow up of patients with bladder squamous cell carcinomas.
In combination with another antimicrobial peptide, psoriasin, LL-37 was even more effective against P.