psoriasin

(sōr-ī-ah'sin),

A compound found in normal skin, increased in psoriasis, which inhibits growth of E. coli, but not of other common skin bacteria.

S100A7

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The function of the S100A7-encoded protein is unknown.

Molecular pathology
S100A7 is overexpressed in the skin lesions of psoriasis, but is not a candidate gene for familial psoriasis.

References in periodicals archive ?

Drugs Profiles discussed in this report includes CIGB-128, CM-101, DLX-1008, koebnerisin, P-529, psoriasin, Recombinant Protein to Inhibit Granzyme B for Cardiovascular and Dermatology Diseases, RXI-109, V-2248.

Keloids Therapeutic Pipeline and Development Review H1 2015 Research Report

Psoriasin (S100A7): a putative urinary marker for the follow up of patients with bladder squamous cell carcinomas.

Intermittent self-catheterization and the risk of squamous cell cancer of the bladder: An emerging clinical entity?

In combination with another antimicrobial peptide, psoriasin, LL-37 was even more effective against P.

Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill Propionibacterium acnes

Additional studies currently are exploring whether the levels of this protein in the CSF are regulated as a function of the progression of dementia, and initial results suggest that psoriasin levels do indeed increase with advancing dementia.

Expression of Psoriasin and Xystain C in the CSF of Early Alzheimer's Disease.

Systems biology in the study of neurological disorders: focus on alzheimer's disease

VIENNA -- Healthy skin secretes an antimicrobial protein called psoriasin that is a potent Escherichia coli-killing compound, Regine Glaser, M.

Psoriasin appears to be the principal reason why cutaneous E.

Endogenous psoriasin protects skin from E. coli infection

Through these studies they discovered a potential tumor marker, psoriasin, excreted in the urine of patients with squamous cell bladder carcinoma (8).

Bladder squamous cell carcinomas express psoriasin and externalize it to the urine.

Identification by proteomic analysis of calreticulin as a marker for bladder cancer and evaluation of the diagnostic accuracy of its detection in urine

People with plaque psoriasis--the most prevalent form of the disease, affecting up to 80 percent of people with psoriasis--will find the Foundation seal on Alva-Amco's Psoriasin Gel in all major pharmacies.

For patients new to non-prescription psoriasis care options, the NPF Seal affirms that the Psoriasin Gel formula is recognized as one that can be expected to offer psoriasis symptom relief.

National Psoriasis Foundation Launches "Seal of Recognition" for Psoriasis Products

Furthermore, 2-DE analysis of urine exhibited the presence of psoriasin in patients with squamous cell carcinoma, which could be used as a biomarker for noninvasive follow up (12).