In another study by Parsad et al24, they compared PUVASOL (oral psoralen
combined with ultraviolet A from sunlight) used alone with a combination of calcipotriol and PUVASOL in right vs left comparative trial.
Eomatium foeniculaceum, Iva axillaris, Psoralen
argophylla are expected to do well on heavy soils, while Astragalus missouriensis and Allium textile are more appropriate for fields on lighter soils.
For more extensive involvement antihistamines, oral retinoids (isotretinoin, acitretin), methotrexate, allopurinol, or phototherapy [7, 8] (narrowband UV-B, broad band UV-B, or psoralen
UV-A) may be appropriate.
Treatment modalities such as topical corticosteroids, topical calcineurin inhibitors, topical retinoids, narrowband ultraviolet B phototherapy, psoralen
and ultraviolet irradiation, and oral acitretin have been used with varying success [2,15,16].
As an alternative to these approaches, psoralen
derivatives and long-wave ultraviolet light treatment can photo-react and irreversibly cross-link viral nucleic acids inside antigen-presenting cells, eliminating viral infectivity  while leaving surface molecules relatively unmodified.
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Phototoxic effects of the drugs can also be used for therapeutic purposes, e.g., application of a photosensitizer such as psoralen
and aminolevulinic acid.
Treatments for more advanced psoriasis include narrow-band ultraviolet B (UVB) light, psoralen
with ultraviolet A (UVA) light retinoids (isotretinoin [Accutane, Claravis], acitretin [Soriatane]), methotrexate (particularly for arthritis), cyclosporine (Neoral, Sandimmune), infliximab (Remicade), etanercept (Enbrel), adalimumab (Humira), apremilast (Otezla), and secukinumab (Cosentyx).
with ultraviolet A (PUVA) treatment is not recommended because the psoralen
can enter breastmilk and lead to light sensitivity (AAD, 2016).
As the main active component of Psoralea corylifolia L., psoralen
was reported possessing cartilage protecting , antitumor [8, 9], immunomodulatory , antivitiligo , and antiurticaria activities .
She used topical tacrolimus, pimecrolimus, mometasone furoate cream, clobetasol propionate cream, topical psoralen
combined with photochemotherapy with UVA, intramuscular triamcinolone acetonide, intramuscular alefacept, subcutaneous etanercept, oral cyclosporine, oral dapsone, and oral prednisone in the past.
, an effective component isolated from Fructus Psoraleae, dose-dependently enhances the production of GAG and type II collagen and increases the expression of SOX9 .