psoralen


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Related to psoralen: Methoxsalen

psoralen

 [sor´ah-len]
any of the constituents of certain plants, such as Psoralea corylifolia, that have the ability to produce phototoxic dermatitis when an individual is first exposed to it and then to sunlight; certain perfumes and drugs, such as methoxsalen, contain psoralens.

psor·a·len

(sōr'ă-len),
A phototoxic drug used by topical or oral administration for the treatment of vitiligo and psoriasis. Also present in oil of bergamot perfume and in fruits and vegetables such as limes, which may cause photosensitization.
See also: PUVA.

psoralen

(sôr′ə-lən)
n.
Any of a group of chemical compounds found in certain plants, used to treat psoriasis and vitiligo.

psoralen

Therapeutics A class of furocoumarins used to treat psoriasis and other skin conditions

psor·a·len

(sōr'ă-len)
A phototoxic drug used topically or orally to treat vitiligo and psoriasis; present in oil of bergamot perfume and in fruits and vegetables such as limes, which may cause photosensitization.

Psoralen

A family of photosensitizing chemicals that can be found in lemons, celery, and other plants. Chemically synthesized versions are used to augment the effects of UVA light treatments.
References in periodicals archive ?
In another study by Parsad et al24, they compared PUVASOL (oral psoralen combined with ultraviolet A from sunlight) used alone with a combination of calcipotriol and PUVASOL in right vs left comparative trial.
Eomatium foeniculaceum, Iva axillaris, Psoralen argophylla are expected to do well on heavy soils, while Astragalus missouriensis and Allium textile are more appropriate for fields on lighter soils.
For more extensive involvement antihistamines, oral retinoids (isotretinoin, acitretin), methotrexate, allopurinol, or phototherapy [7, 8] (narrowband UV-B, broad band UV-B, or psoralen UV-A) may be appropriate.
Treatment modalities such as topical corticosteroids, topical calcineurin inhibitors, topical retinoids, narrowband ultraviolet B phototherapy, psoralen and ultraviolet irradiation, and oral acitretin have been used with varying success [2,15,16].
As an alternative to these approaches, psoralen derivatives and long-wave ultraviolet light treatment can photo-react and irreversibly cross-link viral nucleic acids inside antigen-presenting cells, eliminating viral infectivity [10] while leaving surface molecules relatively unmodified.
Tenders are invited for Supply of Drugs,&-methoxy psoralen,Aripiprazole,Bismuth Iodoform,Cdarcoal,Doxy la mine succinate,Fluconazole,levetiracetam,Lignocaine 10%,N-Acetyl Cysteine,Neosporin powder.in Dr BSA Hospital, Rohini, Delhi
Phototoxic effects of the drugs can also be used for therapeutic purposes, e.g., application of a photosensitizer such as psoralen and aminolevulinic acid.
Treatments for more advanced psoriasis include narrow-band ultraviolet B (UVB) light, psoralen with ultraviolet A (UVA) light retinoids (isotretinoin [Accutane, Claravis], acitretin [Soriatane]), methotrexate (particularly for arthritis), cyclosporine (Neoral, Sandimmune), infliximab (Remicade), etanercept (Enbrel), adalimumab (Humira), apremilast (Otezla), and secukinumab (Cosentyx).
However, psoralen with ultraviolet A (PUVA) treatment is not recommended because the psoralen can enter breastmilk and lead to light sensitivity (AAD, 2016).
As the main active component of Psoralea corylifolia L., psoralen was reported possessing cartilage protecting [7], antitumor [8, 9], immunomodulatory [10], antivitiligo [11], and antiurticaria activities [12].
She used topical tacrolimus, pimecrolimus, mometasone furoate cream, clobetasol propionate cream, topical psoralen combined with photochemotherapy with UVA, intramuscular triamcinolone acetonide, intramuscular alefacept, subcutaneous etanercept, oral cyclosporine, oral dapsone, and oral prednisone in the past.
Psoralen, an effective component isolated from Fructus Psoraleae, dose-dependently enhances the production of GAG and type II collagen and increases the expression of SOX9 [100].