pseudouridine


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pseu·do·u·ri·dine (Ψ, Q),

(sū'dō-yū'ri-dēn),
5-β-d-Ribosyluracil; a naturally occurring isomer of uridine found in transfer ribonucleic acids; unique in that the ribosyl is attached to carbon (C-5) rather than to nitrogen; excreted in urine.

pseu·do·u·ri·dine

(Ψ, Q) (sū'dō-yŭr'i-dēn)
A naturally occurring isomer of uridine found in transfer ribonucleic acids; unique in that the ribosyl is attached to carbon (C-5) rather than to nitrogen; excreted in urine.
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References in periodicals archive ?
Mitochondrial myopathy and sideroblastic anemia (MLASA): Missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudo-uridylation.
Studies have reported that a biomarker panel that includes 5 metabolites: azelaic acid, 2,4-dihydroxypyrimidine, betaalanine, pseudouridine and alpha-hydroxybutyrate can be a candidate model model (37).
Note: 2-OA, 2-oxoadipate; 3-IS, 3-indoxyl sulphate; NAc, N-acetyl groups, PAG, phenylacetylglycine; pCG, p-cresol glucuronide; PU, pseudouridine; SCFAs: short-chain fatty acids; TMA, trimethylamine; TMAO, trimethylamine oxide; [alpha]-KIC, [alpha]- ketoisocaproate; [alpha]-KIV, [alpha]-ketoisovalerate; [alpha]-KMV: [alpha]-keto-[beta]-methyl-N-valerate.
The laboratory uncovered an important function of pseudouridine, the most common type of RNA modification in human cells.
Offer, "Simultaneous determination of purine metabolites, creatinine and pseudouridine in ruminant urine by reversed-phase high-performance liquid chromatography," Journal of Chromatography B: Biomedical Sciences and Applications, vol.
Abbreviations [m.sup.6]A: [N.sup.6]-Methyladenosine [hm.sup.5]C: Hydroxymethylcytosine [PSI]: Pseudouridine [m.sup.1]A: [N.sup.1]-Methyladenosine [m.sup.5]C: 5-Methylcytosine BS-Seq: Bisulfite sequencing MDA-MB-468: MDA468 MEF: Mouse embryo fibroblast MEF-[Dnmt2.sup.-]: Mouse embryo fibroblast with Dnmt2 knockdown WGBS: Whole genome bisulfite sequencing RRBS: Reduced representation bisulfite sequencing mRatio: Methylation ratio OR: Odds ratio DMS: Differential methylation site lncRNA: Long noncoding RNA sncRNA: Small noncoding RNA.
Chromosomal microarray (CMA), performed at the Mayo Clinic (Rochester, MN), demonstrated a 1.7 Mb deletion at Xp22.31 (Figure 2), which included 6 genes; STS, pseudouridine 5'-phosphatase (PUDP), microRNA 4767 (MIR4767), variable charge, X-linked (VCX), patatin-like phospholipase domain containing 4 (PNPLA4), and microRNA 651 (MIR651), which was consistent with the diagnosis of XLI [4, 5].
Deepak et al., "Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate," Metabolomics, vol.
Regulation of nuclear receptor activity by a pseudouridine synthase through posttranscriptional modification of steroid receptor RNA activator.
The sequence of N2 resembled that of an Arabidopsis thaliana MYB transcription factor, that of N4 a multisubstrate pseudouridine synthase 7-like gene from Malus x domestica, N5 a Gossypium hirsutum putative leucine zipper protein.
Nucleosides, as dimethylguanosine and pseudouridine are components of RNA that enter the circulation in larger amounts in cases of enhanced cellular proliferation.
applied a GC-MS-based platform to measure 272 metabolite peaks in plasma obtained from 52 individuals with heart failure and 57 age-matched controls, and identified pseudouridine as the most significant discriminator of disease status (25).