If the platelet count decreases to <90,000/mm3, monitor platelet counts to exclude pseudothrombocytopenia
is caused by platelet clumping, causing a falsely decreased platelet level.
Platelet satellitosis occurs occasionally in peripheral blood samples collected in ethylenediaminetetraacetic acid anticoagulant and thus leads to pseudothrombocytopenia
3] /[micro]L); therefore, EDTA-dependent pseudothrombocytopenia
His platelet count is still low, but they say he has pseudothrombocytopenia
Few postulated mechanisms are macrophage activation leading to platelet destruction (4), increased levels of cytokines (5), immunological destruction due to antiplatelet IgG (6), oxidative stress (7), shortened platelet life span in peripheral blood and sequestration in nonsplenic areas (8) and partly due to pseudothrombocytopenia
due to clumping of platelets (9).
Transient EDTA-dependent pseudothrombocytopenia
in a patient with sepsis.
Pure red cell aplasia and pseudothrombocytopenia
associated with hepatitis A.
The presence of platelet clumps on examination of the peripheral blood smear and normal repeat platelet count using citrated blood confirms pseudothrombocytopenia
as the cause.
Two of the patients developed pseudothrombocytopenia
related to EDTA clumping and did not have thrombocytopenia on repeat analysis of heparinized samples.
A look at the peripheral blood smear is warranted to confirm the count and to rule out pseudothrombocytopenia
due to platelet clumping or satellitism.
Before embarking on a costly search for thrombocytopenia, it is important to rule out the following: 1) pseudothrombocytopenia
caused by platelet clumping by examination of a peripheral blood smear, (2) dilutional thrombocytopenia from massive blood loss and transfusional support with packed RBCs, (2,3) and 3) mild to moderate thrombocytopenia associated with pregnancy in a healthy woman.