Referring to the nonenzymatic, heat-stable peroxidase activity associated with hemeproteins.
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This method detects the pseudoperoxidase activity of hemoglobin; thus, endogenous salivary peroxidases produce false-positive results for hemoglobin.
It is also relevant to mention that above-therapeutic concentrations of mesna, which carry a high reducing capacity, did not cause interference in two Chemstrip 10UA tests that are based on oxidation reactions (glucose by glucose oxidase/peroxidase and hemoglobin with its strong pseudoperoxidase activity).
A second obstacle was the pseudoperoxidase activity of hemoglobin, which can catalyze side reactions with hydrogen peroxide.